TopFIND 4.0

O75648: Mitochondrial tRNA-specific 2-thiouridylase 1

General Information

Protein names
- Mitochondrial tRNA-specific 2-thiouridylase 1
- 2.8.1.14 {ECO:0000250|UniProtKB:Q12093}
- MTO2 homolog
Gene names TRMU
Organism Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID O75648

1

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MQALRHVVCA LSGGVDSAVA ALLLRRRGYQ VTGVFMKNWD SLDEHGVCTA DKDCEDAYRV 
        70         80         90        100        110        120 
CQILDIPFHQ VSYVKEYWND VFSDFLNEYE KGRTPNPDIV CNKHIKFSCF FHYAVDNLGA 
       130        140        150        160        170        180 
DAIATGHYAR TSLEDEEVFE QKHVKKPEGL FRNRFEVRNA VKLLQAADSF KDQTFFLSQV 
       190        200        210        220        230        240 
SQDALRRTIF PLGGLTKEFV KKIAAENRLH HVLQKKESMG MCFIGKRNFE HFLLQYLQPR 
       250        260        270        280        290        300 
PGHFISIEDN KVLGTHKGWF LYTLGQRANI GGLREPWYVV EKDSVKGDVF VAPRTDHPAL 
       310        320        330        340        350        360 
YRDLLRTSRV HWIAEEPPAA LVRDKMMECH FRFRHQMALV PCVLTLNQDG TVWVTAVQAV 
       370        380        390        400        410        420 
RALATGQFAV FYKGDECLGS GKILRLGPSA YTLQKGQRRA GMATESPSDS PEDGPGLSPL 
   
L

Isoforms

- Isoform 2 of Mitochondrial tRNA-specific 2-thiouridylase 1 - Isoform 3 of Mitochondrial tRNA-specific 2-thiouridylase 1 - Isoform 4 of Mitochondrial tRNA-specific 2-thiouridylase 1 - Isoform 5 of Mitochondrial tRNA-specific 2-thiouridylase 1

Sequence View

        10         20         30         40         50         60 
MQALRHVVCA LSGGVDSAVA ALLLRRRGYQ VTGVFMKNWD SLDEHGVCTA DKDCEDAYRV 
        70         80         90        100        110        120 
CQILDIPFHQ VSYVKEYWND VFSDFLNEYE KGRTPNPDIV CNKHIKFSCF FHYAVDNLGA 
       130        140        150        160        170        180 
DAIATGHYAR TSLEDEEVFE QKHVKKPEGL FRNRFEVRNA VKLLQAADSF KDQTFFLSQV 
       190        200        210        220        230        240 
SQDALRRTIF PLGGLTKEFV KKIAAENRLH HVLQKKESMG MCFIGKRNFE HFLLQYLQPR 
       250        260        270        280        290        300 
PGHFISIEDN KVLGTHKGWF LYTLGQRANI GGLREPWYVV EKDSVKGDVF VAPRTDHPAL 
       310        320        330        340        350        360 
YRDLLRTSRV HWIAEEPPAA LVRDKMMECH FRFRHQMALV PCVLTLNQDG TVWVTAVQAV 
       370        380        390        400        410        420 
RALATGQFAV FYKGDECLGS GKILRLGPSA YTLQKGQRRA GMATESPSDS PEDGPGLSPL 
   
L         10         20         30         40         50         60 
MQALRHVVCA LSGGVDSAVA ALLLRRRGYQ VTGVFMKNWD SLDEHGVCTA DKDCEDAYRV 
        70         80         90        100        110        120 
CQILDIPFHQ VSYVKEYWND VFSDFLNEYE KGRTPNPDIV CNKHIKFSCF FHYAVDNLGA 
       130        140        150        160        170        180 
DAIATGHYAR TSLEDEEVFE QKHVKKPEGL FRNRFEVRNA VKLLQAADSF KDQTFFLSQV 
       190        200        210        220        230        240 
SQDALRRTIF PLGGLTKEFV KKIAAENRLH HVLQKKESMG MCFIGKRNFE HFLLQYLQPR 
       250        260        270        280        290        300 
PGHFISIEDN KVLGTHKGWF LYTLGQRANI GGLREPWYVV EKDSVKGDVF VAPRTDHPAL 
       310        320        330        340        350        360 
YRDLLRTSRV HWIAEEPPAA LVRDKMMECH FRFRHQMALV PCVLTLNQDG TVWVTAVQAV 
       370        380        390        400        410        420 
RALATGQFAV FYKGDECLGS GKILRLGPSA YTLQKGQRRA GMATESPSDS PEDGPGLSPL 
   
L         10         20         30         40         50         60 
MQALRHVVCA LSGGVDSAVA ALLLRRRGYQ VTGVFMKNWD SLDEHGVCTA DKDCEDAYRV 
        70         80         90        100        110        120 
CQILDIPFHQ VSYVKEYWND VFSDFLNEYE KGRTPNPDIV CNKHIKFSCF FHYAVDNLGA 
       130        140        150        160        170        180 
DAIATGHYAR TSLEDEEVFE QKHVKKPEGL FRNRFEVRNA VKLLQAADSF KDQTFFLSQV 
       190        200        210        220        230        240 
SQDALRRTIF PLGGLTKEFV KKIAAENRLH HVLQKKESMG MCFIGKRNFE HFLLQYLQPR 
       250        260        270        280        290        300 
PGHFISIEDN KVLGTHKGWF LYTLGQRANI GGLREPWYVV EKDSVKGDVF VAPRTDHPAL 
       310        320        330        340        350        360 
YRDLLRTSRV HWIAEEPPAA LVRDKMMECH FRFRHQMALV PCVLTLNQDG TVWVTAVQAV 
       370        380        390        400        410        420 
RALATGQFAV FYKGDECLGS GKILRLGPSA YTLQKGQRRA GMATESPSDS PEDGPGLSPL 
   
L         10         20         30         40         50         60 
MQALRHVVCA LSGGVDSAVA ALLLRRRGYQ VTGVFMKNWD SLDEHGVCTA DKDCEDAYRV 
        70         80         90        100        110        120 
CQILDIPFHQ VSYVKEYWND VFSDFLNEYE KGRTPNPDIV CNKHIKFSCF FHYAVDNLGA 
       130        140        150        160        170        180 
DAIATGHYAR TSLEDEEVFE QKHVKKPEGL FRNRFEVRNA VKLLQAADSF KDQTFFLSQV 
       190        200        210        220        230        240 
SQDALRRTIF PLGGLTKEFV KKIAAENRLH HVLQKKESMG MCFIGKRNFE HFLLQYLQPR 
       250        260        270        280        290        300 
PGHFISIEDN KVLGTHKGWF LYTLGQRANI GGLREPWYVV EKDSVKGDVF VAPRTDHPAL 
       310        320        330        340        350        360 
YRDLLRTSRV HWIAEEPPAA LVRDKMMECH FRFRHQMALV PCVLTLNQDG TVWVTAVQAV 
       370        380        390        400        410        420 
RALATGQFAV FYKGDECLGS GKILRLGPSA YTLQKGQRRA GMATESPSDS PEDGPGLSPL 
   
L



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Directness:


Physiological Relevance:


Evidence Codes:


Methodology:


Perturbation of System:


Biological System:


Protease Assignment Confidence:


Evidence Names:


Database:


Lab:



Protein Neighborhood

Domains & Features

1 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    O75648-1-unknown MQALRH... 1 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    O75648-1-unknown MQALRH... 1 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt81790
    O75648-1-unknown MQALRH... 1 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt81793

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...LSPLL 421 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    ...LSPLL 421 inferred from isoform by sequence similarity unknown TopFIND inferred from TCt77410

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)