TopFIND 4.0

P11117: Lysosomal acid phosphatase

General Information

Protein names
- Lysosomal acid phosphatase
- LAP
- 3.1.3.2
Gene names ACP2
Organism Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID P11117

2

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MAGKRSGWSR AALLQLLLGV NLVVMPPTRA RSLRFVTLLY RHGDRSPVKT YPKDPYQEEE 
        70         80         90        100        110        120 
WPQGFGQLTK EGMLQHWELG QALRQRYHGF LNTSYHRQEV YVRSTDFDRT LMSAEANLAG 
       130        140        150        160        170        180 
LFPPNGMQRF NPNISWQPIP VHTVPITEDR LLKFPLGPCP RYEQLQNETR QTPEYQNESS 
       190        200        210        220        230        240 
RNAQFLDMVA NETGLTDLTL ETVWNVYDTL FCEQTHGLRL PPWASPQTMQ RLSRLKDFSF 
       250        260        270        280        290        300 
RFLFGIYQQA EKARLQGGVL LAQIRKNLTL MATTSQLPKL LVYSAHDTTL VALQMALDVY 
       310        320        330        340        350        360 
NGEQAPYASC HIFELYQEDS GNFSVEMYFR NESDKAPWPL SLPGCPHRCP LQDFLRLTEP 
       370        380        390        400        410        420 
VVPKDWQQEC QLASGPADTE VIVALAVCGS ILFLLIVLLL TVLFRMQAQP PGYRHVADGE 
   
DHA

Isoforms

- Isoform 2 of Lysosomal acid phosphatase

Sequence View

        10         20         30         40         50         60 
MAGKRSGWSR AALLQLLLGV NLVVMPPTRA RSLRFVTLLY RHGDRSPVKT YPKDPYQEEE 
        70         80         90        100        110        120 
WPQGFGQLTK EGMLQHWELG QALRQRYHGF LNTSYHRQEV YVRSTDFDRT LMSAEANLAG 
       130        140        150        160        170        180 
LFPPNGMQRF NPNISWQPIP VHTVPITEDR LLKFPLGPCP RYEQLQNETR QTPEYQNESS 
       190        200        210        220        230        240 
RNAQFLDMVA NETGLTDLTL ETVWNVYDTL FCEQTHGLRL PPWASPQTMQ RLSRLKDFSF 
       250        260        270        280        290        300 
RFLFGIYQQA EKARLQGGVL LAQIRKNLTL MATTSQLPKL LVYSAHDTTL VALQMALDVY 
       310        320        330        340        350        360 
NGEQAPYASC HIFELYQEDS GNFSVEMYFR NESDKAPWPL SLPGCPHRCP LQDFLRLTEP 
       370        380        390        400        410        420 
VVPKDWQQEC QLASGPADTE VIVALAVCGS ILFLLIVLLL TVLFRMQAQP PGYRHVADGE 
   
DHA



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(REFRESH)

Directness:


Physiological Relevance:


Evidence Codes:


Methodology:


Perturbation of System:


Biological System:


Protease Assignment Confidence:


Evidence Names:


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Lab:



Protein Neighborhood

Domains & Features

2 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    P11117-1-unknown MAGKRS... 1 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt85903
    P11117-31-unknown RSLRFV... 31 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    P11117-31-unknown RSLRFV... 31 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt114808

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...GEDHA 423 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)