TopFIND 4.0

P16232: Corticosteroid 11-beta-dehydrogenase isozyme 1

General Information

Protein names
- Corticosteroid 11-beta-dehydrogenase isozyme 1
- 1.1.1.146
- 11-beta-hydroxysteroid dehydrogenase 1
- 11-DH
- 11-beta-HSD1
Gene names Hsd11b1
Organism Rattus norvegicus
Protease Family
Protease ID
Chromosome location
UniProt ID P16232

2

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MKKYLLPVLV LCLGYYYSTN EEFRPEMLQG KKVIVTGASK GIGREMAYHL SKMGAHVVLT 
        70         80         90        100        110        120 
ARSEEGLQKV VSRCLELGAA SAHYIAGTME DMAFAERFVV EAGKLLGGLD MLILNHITQT 
       130        140        150        160        170        180 
TMSLFHDDIH SVRRSMEVNF LSYVVLSTAA LPMLKQSNGS IAIISSMAGK MTQPLIASYS 
       190        200        210        220        230        240 
ASKFALDGFF STIRKEHLMT KVNVSITLCV LGFIDTETAL KETSGIILSQ AAPKEECALE 
       250        260        270        280    
IIKGTVLRKD EVYYDKSSWT PLLLGNPGRR IMEFLSLRSY NRDLFVSN

Isoforms

- Isoform 11-HSD1B of Corticosteroid 11-beta-dehydrogenase isozyme 1

Sequence View

        10         20         30         40         50         60 
MKKYLLPVLV LCLGYYYSTN EEFRPEMLQG KKVIVTGASK GIGREMAYHL SKMGAHVVLT 
        70         80         90        100        110        120 
ARSEEGLQKV VSRCLELGAA SAHYIAGTME DMAFAERFVV EAGKLLGGLD MLILNHITQT 
       130        140        150        160        170        180 
TMSLFHDDIH SVRRSMEVNF LSYVVLSTAA LPMLKQSNGS IAIISSMAGK MTQPLIASYS 
       190        200        210        220        230        240 
ASKFALDGFF STIRKEHLMT KVNVSITLCV LGFIDTETAL KETSGIILSQ AAPKEECALE 
       250        260        270        280    
IIKGTVLRKD EVYYDKSSWT PLLLGNPGRR IMEFLSLRSY NRDLFVSN



Filter Information:


(REFRESH)

Directness:


Physiological Relevance:


Evidence Codes:


Methodology:


Perturbation of System:


Biological System:


Protease Assignment Confidence:


Evidence Names:


Database:


Lab:



Protein Neighborhood

Domains & Features

2 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    P16232-1-unknown MKKYLL... 1 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    P16232-27-unknown MLQGKK... 27 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt192488

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...LFVSN 288 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    ...LFVSN 288 inferred from isoform by sequence similarity unknown TopFIND inferred from TCt152434

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)