P61086: Ubiquitin-conjugating enzyme E2 K

General Information

Protein names	- Ubiquitin-conjugating enzyme E2 K - 2.3.2.23 {ECO:0000269\|PubMed:20061386} - E2 ubiquitin-conjugating enzyme K - Huntingtin-interacting protein 2 - HIP-2 - Ubiquitin carrier protein - Ubiquitin-conjugating enzyme E2-25 kDa - Ubiquitin-conjugating enzyme E2(25K) - Ubiquitin-conjugating enzyme E2-25K - Ubiquitin-protein ligase
Gene names	UBE2K
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P61086

7 N-termini

1 C-termini

0 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Ubiquitin-conjugating enzyme E2 K - Isoform 3 of Ubiquitin-conjugating enzyme E2 K

Sequence View

        10         20         30         40         50         60
MANIAVQRIK REFKEVLKSE ETSKNQIKVD LVDENFTELR GEIAGPPDTP YEGGRYQLEI
        70         80         90        100        110        120
KIPETYPFNP PKVRFITKIW HPNISSVTGA ICLDILKDQW AAAMTLRTVL LSLQALLAAA
       130        140        150        160        170        180
EPDDPQDAVV ANQYKQNPEM FKQTARLWAH VYAGAPVSSP EYTKKIENLC AMGFDRNAVI
       190        200
VALSSKSWDV ETATELLLSN         10         20         30         40         50         60
MANIAVQRIK REFKEVLKSE ETSKNQIKVD LVDENFTELR GEIAGPPDTP YEGGRYQLEI
        70         80         90        100        110        120
KIPETYPFNP PKVRFITKIW HPNISSVTGA ICLDILKDQW AAAMTLRTVL LSLQALLAAA
       130        140        150        160        170        180
EPDDPQDAVV ANQYKQNPEM FKQTARLWAH VYAGAPVSSP EYTKKIENLC AMGFDRNAVI
       190        200
VALSSKSWDV ETATELLLSN

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

7 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P61086-2-unknown	MANIAV...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P61086-1-unknown	MANIAV...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt93602
P61086-1-unknown	MANIAV...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt93603
P61086-2-Acetylation	ANIAVQ...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P61086-2-Acetylation	ANIAVQ...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
P61086-2-Acetylation	ANIAVQ...	2	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
P61086-2-Acetylation	ANIAVQ...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
P61086-2-Acetylation	ANIAVQ...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt110787
P61086-12-	EFKEVL...	12			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
P61086-12-	EFKEVL...	12			Subtiligase Based Positive Selection		Wells	apopotic_Jurkat_FasL	23264352
P61086-12-unknown	EFKEVL...	12			unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P61086-12-unknown	EFKEVL...	12		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt162262
P61086-15-	EVLKSE...	15			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
P61086-15-	EVLKSE...	15			Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
P61086-15-unknown	EVLKSE...	15			unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P61086-15-unknown	EVLKSE...	15		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt162264
P61086-15-unknown	EVLKSE...	15		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P61086-15-unknown	EVLKSE...	15		inferred from similarity	unknown	UniProtKB		inferred from uniprot (by similarity)

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...LLLSN	200	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...LLLSN	200	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt89220
...LLLSN	200	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt89221

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)