TopFIND 4.0

Q14258: E3 ubiquitin/ISG15 ligase TRIM25

General Information

Protein names
- E3 ubiquitin/ISG15 ligase TRIM25
- 6.3.2.n3 {ECO:0000269|PubMed:16352599}
- Estrogen-responsive finger protein {ECO:0000303|PubMed:8248217}
- RING finger protein 147
- RING-type E3 ubiquitin transferase
- 2.3.2.27 {ECO:0000269|PubMed:17392790}
- RING-type E3 ubiquitin transferase TRIM25 {ECO:0000305}
- Tripartite motif-containing protein 25
- Ubiquitin/ISG15-conjugating enzyme TRIM25
- Zinc finger protein 147
Gene names TRIM25
Organism Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID Q14258

2

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MAELCPLAEE LSCSICLEPF KEPVTTPCGH NFCGSCLNET WAVQGSPYLC PQCRAVYQAR 
        70         80         90        100        110        120 
PQLHKNTVLC NVVEQFLQAD LAREPPADVW TPPARASAPS PNAQVACDHC LKEAAVKTCL 
       130        140        150        160        170        180 
VCMASFCQEH LQPHFDSPAF QDHPLQPPVR DLLRRKCSQH NRLREFFCPE HSECICHICL 
       190        200        210        220        230        240 
VEHKTCSPAS LSQASADLEA TLRHKLTVMY SQINGASRAL DDVRNRQQDV RMTANRKVEQ 
       250        260        270        280        290        300 
LQQEYTEMKA LLDASETTST RKIKEEEKRV NSKFDTIYQI LLKKKSEIQT LKEEIEQSLT 
       310        320        330        340        350        360 
KRDEFEFLEK ASKLRGISTK PVYIPEVELN HKLIKGIHQS TIDLKNELKQ CIGRLQEPTP 
       370        380        390        400        410        420 
SSGDPGEHDP ASTHKSTRPV KKVSKEEKKS KKPPPVPALP SKLPTFGAPE QLVDLKQAGL 
       430        440        450        460        470        480 
EAAAKATSSH PNSTSLKAKV LETFLAKSRP ELLEYYIKVI LDYNTAHNKV ALSECYTVAS 
       490        500        510        520        530        540 
VAEMPQNYRP HPQRFTYCSQ VLGLHCYKKG IHYWEVELQK NNFCGVGICY GSMNRQGPES 
       550        560        570        580        590        600 
RLGRNSASWC VEWFNTKISA WHNNVEKTLP STKATRVGVL LNCDHGFVIF FAVADKVHLM 
       610        620        630    
YKFRVDFTEA LYPAFWVFSA GATLSICSPK 

Isoforms



Sequence View



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Protein Neighborhood

Domains & Features

2 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    Q14258-1-unknown MAELCP... 1 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    Q14258-81- LAREPP... 81 Subtiligase Based Positive Selection Wells apoptotic_MM1SDBJurkat_Mix 23264352

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...ICSPK 630 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)