Q62925: Mitogen-activated protein kinase kinase kinase 1
| Protein names | - Mitogen-activated protein kinase kinase kinase 1 - 2.7.11.25 - MAPK/ERK kinase kinase 1 - MEK kinase 1 - MEKK 1 |
|---|---|
| Gene names | Map3k1 |
| Organism | Rattus norvegicus |
| Protease Family | |
| Protease ID | |
| Chromosome location | |
| UniProt ID | Q62925 |
2
N-termini
1
C-termini
0
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MAAAAGDRAS SSGFPGAAAA SPEAGGGGGA LQGSGAPAAG AGLLRETGSA GRERADWRRQ
70 80 90 100 110 120
QLRKVRSVEL DQLPEQPLFL TASPPCPSTS PSPEPADAAA GASGFQPAAG PPPPGAASRC
130 140 150 160 170 180
GSHSAELAAA RDSGARSPAG AEPPSAAAPS GREMENKETL KGLHKMDDRP EERMIREKLK
190 200 210 220 230 240
ATCMPAWKHE WLERRNRRGP VVVKPIPIKG DGSEMSNLAA ELQGEGQAGS AAPAPKGRRS
250 260 270 280 290 300
PSPGSSPSGR SGKPESPGVR RKRVSPVPFQ SGRITPPRRA PSPDGFSPYS PEETSRRVNK
310 320 330 340 350 360
VMRARLYLLQ QIGPNSFLIG GDSPDNKYRV FIGPQNCSCG RGTFCIHLLF VMLRVFQLEP
370 380 390 400 410 420
SDPMLWRKTL KNFEVESLFQ KYHSRRSSRI KAPSRNTIQK FVSRMSNCHT LSSSSTSTSS
430 440 450 460 470 480
SENSIKDEEE QMCPICLLGM LDEESLTVCE DGCRNKLHHH CMSIWAEECR RNREPLICPL
490 500 510 520 530 540
CRSKWRSHDF YSHELSSPVD SPTSLRGVQQ PSSPQQPVAG SQRRNQESNF NLTHYGTQQI
550 560 570 580 590 600
PPAYKDLAEP WIQAFGMELV GCLFSRNWNV REMALRRLSH DVSGALLLAN GESTGTSGGG
610 620 630 640 650 660
SGGSLSAGAA SGSSQPSISG DVVEAFCSVL SIVCADPVYK VYVAALKTLR AMLVYTPCHS
670 680 690 700 710 720
LAERIKLQRL LRPVVDTILV KCADANSRTS QLSISTLLEL CKGQAGELAV GREILKAGSI
730 740 750 760 770 780
GVGGVDYVLS CILGNQAESN NWQELLGRLC LIDRLLLEIS AEFYPHIVST DVSQAEPVEI
790 800 810 820 830 840
RYKKLLSLLA FALQSIDNSH SMVGKLSRRI YLSSARMVTT VPPLFSKLVT MLSASGSSHF
850 860 870 880 890 900
ARMRRRLMAI ADEVEIAEVI QLGSEDTLDG QQDSSQALAP PRYPESSSLE HTAHVEKTGK
910 920 930 940 950 960
GLKATRLSAS SEDISDRLAG VSVGLPSSAT TEQPKPTVQT KGRPHSQCLN SSPLSPPQLM
970 980 990 1000 1010 1020
FPAISAPCSS APSVPAGSVT DASKHRPRAF VPCKIPSASP QTQRKFSLQF QRTCSENRDS
1030 1040 1050 1060 1070 1080
EKLSPVFTQS RPPPSSNIHR AKASRPVPGS TSKLGDASKN SMTLDLNSAS QCDDSFGSGS
1090 1100 1110 1120 1130 1140
NSGSAVIPSE ETAFTPAEDK CRLDVNPELN SSIEDLLEAS MPSSDTTVTF KSEVAVLSPE
1150 1160 1170 1180 1190 1200
KAESDDTYKD DVNHNQKCKE KMEAEEEEAL AIAMAMSASQ DALPIVPQLQ VENGEDIIII
1210 1220 1230 1240 1250 1260
QQDTPETLPG HTKANEPYRE DTEWLKGQQI GLGAFSSCYQ AQDVGTGTLM AVKQVTYVRN
1270 1280 1290 1300 1310 1320
TSSEQEEVVE ALREEIRMMS HLNHPNIIRM LGATCEKSNY NLFIEWMAGA SVAHLLSKYG
1330 1340 1350 1360 1370 1380
AFKESVVINY TEQLLRGLSY LHENQIIHRD VKGANLLIDS TGQRLRIADF GAAARLASKG
1390 1400 1410 1420 1430 1440
TGAGEFQGQL LGTIAFMAPE VLRGQQYGRS CDVWSVGCAI IEMACAKPPW NAEKHSNHLA
1450 1460 1470 1480 1490
LIFKIASATT APSIPSHLSP GLRDVALRCL ELQPQDRPPS RELLKHPVFR TTW
Isoforms
Sequence View
Protein Neighborhood
Domains & Features
2 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates
N-termini
| Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
|---|---|---|---|---|---|---|---|---|---|
| Q62925-2-unknown | MAAAAG... | 1 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
| Q62925-2-Acetylation | AAAAGD... | 2 | acetylation- | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot |
C-termini
| Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|---|---|---|---|---|---|---|---|
| ...FRTTW | 1493 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot |
Cleavages
| Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|
Substrates
| Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|