TopFIND 4.0

Q8IWU2: Serine/threonine-protein kinase LMTK2

General Information

Protein names
- Serine/threonine-protein kinase LMTK2
- 2.7.11.1
- Apoptosis-associated tyrosine kinase 2
- Brain-enriched kinase
- hBREK
- CDK5/p35-regulated kinase
- CPRK
- Kinase/phosphatase/inhibitor 2
- Lemur tyrosine kinase 2
- Serine/threonine-protein kinase KPI-2
Gene names LMTK2
Organism Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID Q8IWU2

3

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MPGPPALRRR LLLLLLVLLI AGSAGAAPLP QTGAGEAPPA AEVSSSFVIL CVCSLIILIV 
        70         80         90        100        110        120 
LIANCVSCCK DPEIDFKEFE DNFDDEIDFT PPAEDTPSVQ SPAEVFTLSV PNISLPAPSQ 
       130        140        150        160        170        180 
FQPSVEGLKS QVARHSLNYI QEIGNGWFGK VLLGEIYTGT SVARVIVKEL KASANPKEQD 
       190        200        210        220        230        240 
TFLKNGEPYY ILQHPNILQC VGQCVEAIPY LLVFEFCDLG DLKAYLRSEQ EHMRGDSQTM 
       250        260        270        280        290        300 
LLQRMACEVA AGLAAMHKLH FLHSDLALRN CFLTSDLNVK VGDYGIGFSR YKEDYIETDD 
       310        320        330        340        350        360 
KKVFPLRWTA PELVTSFQDR LLTADQTKYS NIWSLGVTLW ELFDNAAQPY SNLSNLDVLN 
       370        380        390        400        410        420 
QVIRERDTKL PKPQLEQPYS DRWYEVLQFC WLSPEKRPAA EDVHRLLTYL RLQSQRDSEV 
       430        440        450        460        470        480 
DFEQQWNALK PNTNSRDSSN NAAFPILDHF ARDRLGREME EVLTVTETSQ GLSFEYVWEA 
       490        500        510        520        530        540 
AKHDHFDERS RGHLDEGLSY TSIFYPVEVF ESSLSDPGPG KQDDSGQDVP LRVPGVVPVF 
       550        560        570        580        590        600 
DAHNLSVGSD YYIQLEEKSG SNLELDYPPA LLTTDMDNPE RTGPELSQLT ALRSVELEES 
       610        620        630        640        650        660 
STDEDFFQSS TDPKDSSLPG DLHVTSGPES PFNNIFNDVD KSEDLPSHQK IFDLMELNGV 
       670        680        690        700        710        720 
QADFKPATLS SSLDNPKESV ITGHFEKEKP RKIFDSEPLC LSDNLMHQDN FDPLNVQELS 
       730        740        750        760        770        780 
ENFLFLQEKN LLKGSLSSKE HINDLQTELK NAGFTEAMLE TSCRNSLDTE LQFAENKPGL 
       790        800        810        820        830        840 
SLLQENVSTK GDDTDVMLTG DTLSTSLQSS PEVQVPPTSF ETEETPRRVP PDSLPTQGET 
       850        860        870        880        890        900 
QPTCLDVIVP EDCLHQDISP DAVTVPVEIL STDARTHSLD NRSQDSPGES EETLRLTESD 
       910        920        930        940        950        960 
SVLADDILAS RVSVGSSLPE LGQELHNKPF SEDHHSHRRL EKNLEAVETL NQLNSKDAAK 
       970        980        990       1000       1010       1020 
EAGLVSALSS DSTSQDSLLE DSLSAPFPAS EPSLETPDSL ESVDVHEALL DSLGSHTPQK 
      1030       1040       1050       1060       1070       1080 
LVPPDKPADS GYETENLESP EWTLHPAPEG TADSEPATTG DGGHSGLPPN PVIVISDAGD 
      1090       1100       1110       1120       1130       1140 
GHRGTEVTPE TFTAGSQGSY RDSAYFSDND SEPEKRSEEV PGTSPSALVL VQEQPLPEPV 
      1150       1160       1170       1180       1190       1200 
LPEQSPAAQD SCLEARKSQP DESCLSALHN SSDLELRATP EPAQTGVPQQ VHPTEDEASS 
      1210       1220       1230       1240       1250       1260 
PWSVLNAELS SGDDFETQDD RPCTLASTGT NTNELLAYTN SALDKSLSSH SEGPKLKEPD 
      1270       1280       1290       1300       1310       1320 
IEGKYLGKLG VSGMLDLSED GMDADEEDEN SDDSDEDLRA FNLHSLSSES EDETEHPVPI 
      1330       1340       1350       1360       1370       1380 
ILSNEDGRHL RSLLKPTAAN APDPLPEDWK KEKKAVTFFD DVTVYLFDQE TPTKELGPCG 
      1390       1400       1410       1420       1430       1440 
GEACGPDLSG PAPASGSPYL SRCINSESST DEEGGGFEWD DDFSPDPFMS KTTSNLLSSK 
      1450       1460       1470       1480       1490       1500 
PSLQTSKYFS PPPPARSTEQ SWPHSAPYSR FSISPANIAS FSLTHLTDSD IEQGGSSEDG 
   
EKD

Isoforms



Sequence View



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Protein Neighborhood

Domains & Features

3 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...DGEKD 1503 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)