Q9BQI3: Eukaryotic translation initiation factor 2-alpha kinase 1

General Information

Protein names	- Eukaryotic translation initiation factor 2-alpha kinase 1 - 2.7.11.1 - Heme-controlled repressor - HCR - Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase - Heme-regulated inhibitor - Hemin-sensitive initiation factor 2-alpha kinase
Gene names	EIF2AK1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9BQI3

3 N-termini

1 C-termini

0 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MQGGNSGVRK REEEGDGAGA VAAPPAIDFP AEGPDPEYDE SDVPAEIQVL KEPLQQPTFP
        70         80         90        100        110        120
FAVANQLLLV SLLEHLSHVH EPNPLRSRQV FKLLCQTFIK MGLLSSFTCS DEFSSLRLHH
       130        140        150        160        170        180
NRAITHLMRS AKERVRQDPC EDISRIQKIR SREVALEAQT SRYLNEFEEL AILGKGGYGR
       190        200        210        220        230        240
VYKVRNKLDG QYYAIKKILI KGATKTVCMK VLREVKVLAG LQHPNIVGYH TAWIEHVHVI
       250        260        270        280        290        300
QPRADRAAIE LPSLEVLSDQ EEDREQCGVK NDESSSSSII FAEPTPEKEK RFGESDTENQ
       310        320        330        340        350        360
NNKSVKYTTN LVIRESGELE STLELQENGL AGLSASSIVE QQLPLRRNSH LEESFTSTEE
       370        380        390        400        410        420
SSEENVNFLG QTEAQYHLML HIQMQLCELS LWDWIVERNK RGREYVDESA CPYVMANVAT
       430        440        450        460        470        480
KIFQELVEGV FYIHNMGIVH RDLKPRNIFL HGPDQQVKIG DFGLACTDIL QKNTDWTNRN
       490        500        510        520        530        540
GKRTPTHTSR VGTCLYASPE QLEGSEYDAK SDMYSLGVVL LELFQPFGTE MERAEVLTGL
       550        560        570        580        590        600
RTGQLPESLR KRCPVQAKYI QHLTRRNSSQ RPSAIQLLQS ELFQNSGNVN LTLQMKIIEQ
       610        620        630
EKEIAELKKQ LNLLSQDKGV RDDGKDGGVG

Isoforms

- Isoform 2 of Eukaryotic translation initiation factor 2-alpha kinase 1

Sequence View

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Evidence Names:

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Protein Neighborhood

Domains & Features

3 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q9BQI3-1-	MQGGNS...	1		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q9BQI3-1-unknown	MQGGNS...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9BQI3-1-unknown	MQGGNS...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt73500
Q9BQI3-1-unknown	MQGGNS...	1		unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q9BQI3-132-unknown	KERVRQ...	132	inferred from electronic annotation	unknown	TISdb		inferred from TISdb
Q9BQI3-132-unknown	KERVRQ...	132	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt197437

C-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
	...DGGVG	630	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
	...DGGVG	630	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt69118

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)