TopFIND 4.0

Q9UPZ9: Serine/threonine-protein kinase ICK

General Information

Protein names
- Serine/threonine-protein kinase ICK
- 2.7.11.1 {ECO:0000269|PubMed:10699974}
- Intestinal cell kinase
- hICK
- Laryngeal cancer kinase 2
- LCK2
- MAK-related kinase
- MRK
Gene names ICK
Organism Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID Q9UPZ9

1

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MNRYTTIRQL GDGTYGSVLL GRSIESGELI AIKKMKRKFY SWEECMNLRE VKSLKKLNHA 
        70         80         90        100        110        120 
NVVKLKEVIR ENDHLYFIFE YMKENLYQLI KERNKLFPES AIRNIMYQIL QGLAFIHKHG 
       130        140        150        160        170        180 
FFHRDLKPEN LLCMGPELVK IADFGLAREI RSKPPYTDYV STRWYRAPEV LLRSTNYSSP 
       190        200        210        220        230        240 
IDVWAVGCIM AEVYTLRPLF PGASEIDTIF KICQVLGTPK KTDWPEGYQL SSAMNFRWPQ 
       250        260        270        280        290        300 
CVPNNLKTLI PNASSEAVQL LRDMLQWDPK KRPTASQALR YPYFQVGHPL GSTTQNLQDS 
       310        320        330        340        350        360 
EKPQKGILEK AGPPPYIKPV PPAQPPAKPH TRISSRQHQA SQPPLHLTYP YKAEVSRTDH 
       370        380        390        400        410        420 
PSHLQEDKPS PLLFPSLHNK HPQSKITAGL EHKNGEIKPK SRRRWGLISR STKDSDDWAD 
       430        440        450        460        470        480 
LDDLDFSPSL SRIDLKNKKR QSDDTLCRFE SVLDLKPSEP VGTGNSAPTQ TSYQRRDTPT 
       490        500        510        520        530        540 
LRSAAKQHYL KHSRYLPGIS IRNGILSNPG KEFIPPNPWS SSGLSGKSSG TMSVISKVNS 
       550        560        570        580        590        600 
VGSSSTSSSG LTGNYVPSFL KKEIGSAMQR VHLAPIPDPS PGYSSLKAMR PHPGRPFFHT 
       610        620        630    
QPRSTPGLIP RPPAAQPVHG RTDWASKYAS RR

Isoforms

- Isoform 2 of Serine/threonine-protein kinase ICK

Sequence View

        10         20         30         40         50         60 
MNRYTTIRQL GDGTYGSVLL GRSIESGELI AIKKMKRKFY SWEECMNLRE VKSLKKLNHA 
        70         80         90        100        110        120 
NVVKLKEVIR ENDHLYFIFE YMKENLYQLI KERNKLFPES AIRNIMYQIL QGLAFIHKHG 
       130        140        150        160        170        180 
FFHRDLKPEN LLCMGPELVK IADFGLAREI RSKPPYTDYV STRWYRAPEV LLRSTNYSSP 
       190        200        210        220        230        240 
IDVWAVGCIM AEVYTLRPLF PGASEIDTIF KICQVLGTPK KTDWPEGYQL SSAMNFRWPQ 
       250        260        270        280        290        300 
CVPNNLKTLI PNASSEAVQL LRDMLQWDPK KRPTASQALR YPYFQVGHPL GSTTQNLQDS 
       310        320        330        340        350        360 
EKPQKGILEK AGPPPYIKPV PPAQPPAKPH TRISSRQHQA SQPPLHLTYP YKAEVSRTDH 
       370        380        390        400        410        420 
PSHLQEDKPS PLLFPSLHNK HPQSKITAGL EHKNGEIKPK SRRRWGLISR STKDSDDWAD 
       430        440        450        460        470        480 
LDDLDFSPSL SRIDLKNKKR QSDDTLCRFE SVLDLKPSEP VGTGNSAPTQ TSYQRRDTPT 
       490        500        510        520        530        540 
LRSAAKQHYL KHSRYLPGIS IRNGILSNPG KEFIPPNPWS SSGLSGKSSG TMSVISKVNS 
       550        560        570        580        590        600 
VGSSSTSSSG LTGNYVPSFL KKEIGSAMQR VHLAPIPDPS PGYSSLKAMR PHPGRPFFHT 
       610        620        630    
QPRSTPGLIP RPPAAQPVHG RTDWASKYAS RR



Filter Information:


(REFRESH)

Directness:


Physiological Relevance:


Evidence Codes:


Methodology:


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Protease Assignment Confidence:


Evidence Names:


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Protein Neighborhood

Domains & Features

1 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    Q9UPZ9-1-unknown MNRYTT... 1 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    Q9UPZ9-1-unknown MNRYTT... 1 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt77490

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...YASRR 632 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)