A Comprehensive Knowledgebase
331,278 natural and neo N- and C- termini and 35,044 protease cleavage sites listed
UniProt release used: 2019_07
MEROPS release used: 12.1
Covers H. sapiens, M. musculus, R. norvegicus, S. cerevisiae,
A. thaliana, E. coli, C. elegans and D. rerio
What TopFIND Provides
Integration of protein termini & function with proteolytic processing, alternative transcription & translation.
Displays proteases and substrates within their protease web including detailed evidence information
TopFINDer automates analysis and functional annotation of proteomics-derived termini sets
PathFINDer identifies indirect protease-substrate connections for the evaluation of complex processes
Contribute
Submit your N- or C-termini datasets
Contribute information on protein cleavages
Provide detailed experimental description, sample information and raw data