PathFINDer is TopFIND's protease web explorer inspired by Fortelny et al, PLoS Biology, 2014. The protease web is a network of proteases and their inhibitors. Proteases cleave other proteases and inhibitors of other proteases in vivo. Changes of the activity of one protease can thereby influence the cleavage of substrates of other proteases indirectly. PathFINDer uses a graph to model known protease interactions as a network and finds paths in this network. These paths represent biological pathways thus enabling mechanistic insights.
More information and citation: Fortelny et al, NAR, 2014 [pdf]