TopFIND 4.0

Evidence Source

Description Imported from Merops: Merops-evidence: experimental | Merops-type: physiological | Merops-range: 25-54,89-110

Method

Protease identification: VT | Substrate identification: MS

Experimental system

unknown

Perturbation

none

Protease inhibitor(s) used


Directness

unknown

Physiological relevance

yes

Evidence Code(s)

    inferred from experiment

Database / Laboratory

    - Lab: Authier F
    - DB: MEROPS

Raw data repository

Evidence for:

0

N-termini

0

C-termini


Publication(s)

Endosomal proteolysis of internalised [ArgA0]-human insulin at neutral pH generates the mature insulin peptide in rat liver in vivo.

Kouach M, Desbuquois B, Authier F

Diabetologia. 2009 Dec;52(12):2621-32. doi: 10.1007/s00125-009-1551-0. Epub 2009 Oct 16. PMID: 19834685