Evidence Source

Description	Imported from Merops: KO/IN Merops-evidence: experimental \| Merops-type: physiological \| Merops-range: 20-956
Method	Substrate identification: MS
Experimental system	unknown
Perturbation	none
Protease inhibitor(s) used
Directness	unknown
Physiological relevance	yes
Evidence Code(s)	inferred from experiment
Database / Laboratory	- Lab: Suzuki T - DB: MEROPS
Raw data repository

Evidence for:

0 N-termini

0 C-termini

Publication(s)	Alcadein cleavages by amyloid beta-precursor protein (APP) alpha- and gamma-secretases generate small peptides, p3-Alcs, indicating Alzheimer disease-related gamma-secretase dysfunction. Hata S, Fujishige S, Araki Y, Kato N, Araseki M, Nishimura M, Hartmann D, Saftig P, Fahrenholz F, Taniguchi M, Urakami K, Akatsu H, Martins RN, Yamamoto K, Maeda M, Yamamoto T, Nakaya T, Gandy S, Suzuki T J Biol Chem. 2009 Dec 25;284(52):36024-33. doi: 10.1074/jbc.M109.057497. Epub 2009 Oct 28. PMID: 19864413

Publication(s)

Alcadein cleavages by amyloid beta-precursor protein (APP) alpha- and gamma-secretases generate small peptides, p3-Alcs, indicating Alzheimer disease-related gamma-secretase dysfunction.

Hata S, Fujishige S, Araki Y, Kato N, Araseki M, Nishimura M, Hartmann D, Saftig P, Fahrenholz F, Taniguchi M, Urakami K, Akatsu H, Martins RN, Yamamoto K, Maeda M, Yamamoto T, Nakaya T, Gandy S, Suzuki T

J Biol Chem. 2009 Dec 25;284(52):36024-33. doi: 10.1074/jbc.M109.057497. Epub 2009 Oct 28. PMID: 19864413