Evidence Source
| Description | Imported from Merops: Merops-evidence: experimental | Merops-type: physiological | Merops-range: 1-1248 |
|---|---|
Method |
|
Experimental system |
unknown |
Perturbation |
none |
Protease inhibitor(s) used |
|
Directness |
unknown |
Physiological relevance |
yes |
Evidence Code(s) |
inferred from experiment |
Database / Laboratory |
- Lab: Cohen GM - DB: MEROPS |
Raw data repository |
Evidence for:
0
N-termini
0
C-termini
Publication(s) |
Caspase-3 cleaves Apaf-1 into an approximately 30 kDa fragment that associates with an inappropriately oligomerized and biologically inactive approximately 1.4 MDa apoptosome complex. Bratton SB, Walker G, Roberts DL, Cain K, Cohen GM Cell Death Differ. 2001 Apr;8(4):425-33. PMID: 11550094 |
|---|