TopFIND 4.0

Evidence Source

Description Imported from Merops: Merops-evidence: experimental | Merops-type: physiological | Merops-range: 2-586

Method

Substrate identification: NT

Experimental system

unknown

Perturbation

none

Protease inhibitor(s) used


Directness

unknown

Physiological relevance

yes

Evidence Code(s)

    inferred from experiment

Database / Laboratory

    - Lab: Lieberman J
    - DB: MEROPS

Raw data repository

Evidence for:

0

N-termini

0

C-termini


Publication(s)

Granzymes A and B directly cleave lamins and disrupt the nuclear lamina during granule-mediated cytolysis.

Zhang D, Beresford PJ, Greenberg AH, Lieberman J

Proc Natl Acad Sci U S A. 2001 May 8;98(10):5746-51. Epub 2001 May 1. PMID: 11331782