Evidence Source
| Description | Imported from Merops: Merops-evidence: experimental | Merops-type: physiological | Merops-range: 1-140 |
|---|---|
Method |
Substrate identification: NT |
Experimental system |
unknown |
Perturbation |
none |
Protease inhibitor(s) used |
|
Directness |
unknown |
Physiological relevance |
yes |
Evidence Code(s) |
inferred from experiment |
Database / Laboratory |
- Lab: Yen SH - DB: MEROPS |
Raw data repository |
Evidence for:
0
N-termini
0
C-termini
Publication(s) |
Cathepsin D is the main lysosomal enzyme involved in the degradation of alpha-synuclein and generation of its carboxy-terminally truncated species. Sevlever D, Jiang P, Yen SH Biochemistry. 2008 Sep 9;47(36):9678-87. doi: 10.1021/bi800699v. Epub 2008 Aug 15. PMID: 18702517 |
|---|