Evidence Source

Description	Imported from Merops: Merops-evidence: experimental \| Merops-type: physiological \| Merops-range: 1-551
Method
Experimental system	unknown
Perturbation	none
Protease inhibitor(s) used
Directness	unknown
Physiological relevance	yes
Evidence Code(s)	inferred from experiment
Database / Laboratory	- Lab: Falk RJ - DB: MEROPS
Raw data repository

Evidence for:

0 N-termini

0 C-termini

Publication(s)	Novel effects of neutrophil-derived proteinase 3 and elastase on the vascular endothelium involve in vivo cleavage of NF-kappaB and proapoptotic changes in JNK, ERK, and p38 MAPK signaling pathways. Preston GA, Zarella CS, Pendergraft WF 3rd, Rudolph EH, Yang JJ, Sekura SB, Jennette JC, Falk RJ J Am Soc Nephrol. 2002 Dec;13(12):2840-9. PMID: 12444202

Publication(s)

Novel effects of neutrophil-derived proteinase 3 and elastase on the vascular endothelium involve in vivo cleavage of NF-kappaB and proapoptotic changes in JNK, ERK, and p38 MAPK signaling pathways.

Preston GA, Zarella CS, Pendergraft WF 3rd, Rudolph EH, Yang JJ, Sekura SB, Jennette JC, Falk RJ

J Am Soc Nephrol. 2002 Dec;13(12):2840-9. PMID: 12444202