Evidence Source
| Description | Imported from Merops: Merops-evidence: experimental | Merops-type: physiological | Merops-range: 18-477 |
|---|---|
Method |
Substrate identification: CS |
Experimental system |
unknown |
Perturbation |
none |
Protease inhibitor(s) used |
|
Directness |
unknown |
Physiological relevance |
yes |
Evidence Code(s) |
inferred from experiment |
Database / Laboratory |
- Lab: Chiarelli C - DB: MEROPS |
Raw data repository |
Evidence for:
0
N-termini
0
C-termini
Publication(s) |
Furin directly cleaves proMMP-2 in the trans-Golgi network resulting in a nonfunctioning proteinase. Cao J, Rehemtulla A, Pavlaki M, Kozarekar P, Chiarelli C J Biol Chem. 2005 Mar 25;280(12):10974-80. Epub 2005 Jan 6. PMID: 15637056 |
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