TopFIND 4.0

Evidence Source

Description Imported from Merops: Merops-evidence: experimental | Merops-type: physiological | Merops-range: 37-264

Method

Protease identification: IN | Substrate identification: MS

Experimental system

unknown

Perturbation

none

Protease inhibitor(s) used


Directness

unknown

Physiological relevance

yes

Evidence Code(s)

    inferred from experiment

Database / Laboratory

    - Lab: Lieberman J
    - DB: MEROPS

Raw data repository

Evidence for:

0

N-termini

0

C-termini


Publication(s)

Granzyme A cleaves a mitochondrial complex I protein to initiate caspase-independent cell death.

Martinvalet D, Dykxhoorn DM, Ferrini R, Lieberman J

Cell. 2008 May 16;133(4):681-92. doi: 10.1016/j.cell.2008.03.032. PMID: 18485875