TopFIND 4.0

Evidence Source

Description Imported from Merops: Merops-evidence: experimental | Merops-type: physiological | Merops-range: 1-1130

Method

Protease identification: IN | Substrate identification: CS

Experimental system

unknown

Perturbation

none

Protease inhibitor(s) used


Directness

unknown

Physiological relevance

yes

Evidence Code(s)

    inferred from experiment

Database / Laboratory

    - Lab: Craik CS
    - DB: MEROPS

Raw data repository

Evidence for:

0

N-termini

0

C-termini


Publication(s)

Granzyme B proteolyzes receptors important to proliferation and survival, tipping the balance toward apoptosis.

Loeb CR, Harris JL, Craik CS

J Biol Chem. 2006 Sep 22;281(38):28326-35. Epub 2006 Jun 23. PMID: 16798735