Evidence Source

Description	Imported from Merops: Merops-evidence: experimental \| Merops-type: physiological \| Merops-range: 1-331
Method	Protease identification: IN \| Substrate identification: NT
Experimental system	unknown
Perturbation	none
Protease inhibitor(s) used
Directness	unknown
Physiological relevance	yes
Evidence Code(s)	inferred from experiment
Database / Laboratory	- Lab: Fan Z - DB: MEROPS
Raw data repository

Evidence for:

Publication(s)	Granzyme M directly cleaves inhibitor of caspase-activated DNase (CAD) to unleash CAD leading to DNA fragmentation. Lu H, Hou Q, Zhao T, Zhang H, Zhang Q, Wu L, Fan Z J Immunol. 2006 Jul 15;177(2):1171-8. PMID: 16818775

Publication(s)

Granzyme M directly cleaves inhibitor of caspase-activated DNase (CAD) to unleash CAD leading to DNA fragmentation.

Lu H, Hou Q, Zhao T, Zhang H, Zhang Q, Wu L, Fan Z

J Immunol. 2006 Jul 15;177(2):1171-8. PMID: 16818775