TopFIND 4.0

Evidence Source

Description Imported from Merops: Merops-evidence: experimental | Merops-type: physiological | Merops-range: 1-269

Method

Protease identification: VT | Substrate identification: NT

Experimental system

unknown

Perturbation

none

Protease inhibitor(s) used


Directness

unknown

Physiological relevance

yes

Evidence Code(s)

    inferred from experiment

Database / Laboratory

    - Lab: Kaushal GP
    - DB: MEROPS

Raw data repository

Evidence for:

0

N-termini

0

C-termini


Publication(s)

Meprin A and meprin alpha generate biologically functional IL-1beta from pro-IL-1beta.

Herzog C, Haun RS, Kaushal V, Mayeux PR, Shah SV, Kaushal GP

Biochem Biophys Res Commun. 2009 Feb 20;379(4):904-8. doi: 10.1016/j.bbrc.2008.12.161. Epub 2009 Jan 7. PMID: 19135030