TopFIND 4.0

Evidence Source

Description Imported from Merops: AB/MU Merops-evidence: experimental | Merops-type: physiological | Merops-range: 153-692

Method

Protease identification: NA

Experimental system

unknown

Perturbation

none

Protease inhibitor(s) used


Directness

unknown

Physiological relevance

yes

Evidence Code(s)

    inferred from experiment

Database / Laboratory

    - Lab: Seidah NG
    - DB: MEROPS

Raw data repository

Evidence for:

0

N-termini

0

C-termini


Publication(s)

The proprotein convertase (PC) PCSK9 is inactivated by furin and/or PC5/6A: functional consequences of natural mutations and post-translational modifications.

Benjannet S, Rhainds D, Hamelin J, Nassoury N, Seidah NG

J Biol Chem. 2006 Oct 13;281(41):30561-72. Epub 2006 Aug 15. PMID: 16912035