TopFIND 4.0

Evidence Source

Description Imported from Merops: Merops-evidence: experimental | Merops-type: physiological | Merops-range: 24-33

Method

Substrate identification: CS

Experimental system

unknown

Perturbation

none

Protease inhibitor(s) used


Directness

unknown

Physiological relevance

yes

Evidence Code(s)

    inferred from experiment

Database / Laboratory

    - Lab: Smith AI
    - DB: MEROPS

Raw data repository

Evidence for:

0

N-termini

0

C-termini


Publication(s)

Evidence for a two-step mechanism of gonadotropin-releasing hormone metabolism by prolyl endopeptidase and metalloendopeptidase EC 3.4.24.15 in ovine hypothalamic extracts.

Lew RA, Tetaz TJ, Glucksman MJ, Roberts JL, Smith AI

J Biol Chem. 1994 Apr 29;269(17):12626-32. PMID: 8175672