TopFIND 4.0

Evidence Source

Description Imported from Merops: Merops-evidence: experimental | Merops-type: physiological | Merops-range: 23-230

Method

Protease identification: IN | Substrate identification: MS

Experimental system

unknown

Perturbation

none

Protease inhibitor(s) used


Directness

unknown

Physiological relevance

yes

Evidence Code(s)

    inferred from experiment

Database / Laboratory

    - Lab: Hooper NM
    - DB: MEROPS

Raw data repository

Evidence for:

0

N-termini

0

C-termini


Publication(s)

Role of ADAMs in the ectodomain shedding and conformational conversion of the prion protein.

Taylor DR, Parkin ET, Cocklin SL, Ault JR, Ashcroft AE, Turner AJ, Hooper NM

J Biol Chem. 2009 Aug 21;284(34):22590-600. doi: 10.1074/jbc.M109.032599. Epub 2009 Jun 29. PMID: 19564338