TopFIND 4.0

Evidence Source

Description Imported from Merops: Merops-evidence: experimental | Merops-type: physiological | Merops-range: 18-722

Method


Experimental system

unknown

Perturbation

none

Protease inhibitor(s) used


Directness

unknown

Physiological relevance

yes

Evidence Code(s)

    inferred from experiment

Database / Laboratory

    - Lab: Logeat F
    - DB: MEROPS

Raw data repository

Evidence for:

0

N-termini

0

C-termini


Publication(s)

The Notch ligand Delta1 is sequentially cleaved by an ADAM protease and gamma-secretase.

Six E, Ndiaye D, Laabi Y, Brou C, Gupta-Rossi N, Israel A, Logeat F

Proc Natl Acad Sci U S A. 2003 Jun 24;100(13):7638-43. Epub 2003 Jun 6. PMID: 12794186