TopFIND 4.0

Evidence Source

Description Imported from Merops: Merops-evidence: experimental | Merops-type: physiological | Merops-range: 182-1241

Method

Substrate identification: MS

Experimental system

unknown

Perturbation

none

Protease inhibitor(s) used


Directness

unknown

Physiological relevance

yes

Evidence Code(s)

    inferred from experiment

Database / Laboratory

    - Lab: Konttinen YT
    - DB: MEROPS

Raw data repository

Evidence for:

0

N-termini

0

C-termini


Publication(s)

Trypsin-2 degrades human type II collagen and is expressed and activated in mesenchymally transformed rheumatoid arthritis synovitis tissue.

Stenman M, Ainola M, Valmu L, Bjartell A, Ma G, Stenman UH, Sorsa T, Luukkainen R, Konttinen YT

Am J Pathol. 2005 Oct;167(4):1119-24. PMID: 16192646