TopFIND 4.0

Evidence Source

Description Imported from Merops: Merops-evidence: experimental | Merops-type: physiological | Merops-range: 1-247

Method

Protease identification: VT | Substrate identification: MS

Experimental system

unknown

Perturbation

none

Protease inhibitor(s) used


Directness

unknown

Physiological relevance

yes

Evidence Code(s)

    inferred from experiment

Database / Laboratory

Raw data repository

Evidence for:

0

N-termini

0

C-termini


Publication(s)

Structure of granzyme C reveals an unusual mechanism of protease autoinhibition.

Kaiserman D, Buckle AM, Van Damme P, Irving JA, Law RH, Matthews AY, Bashtannyk-Puhalovich T, Langendorf C, Thompson P, Vandekerckhove J, Gevaert K, Whisstock JC, Bird PI

Proc Natl Acad Sci U S A. 2009 Apr 7;106(14):5587-92. doi: 10.1073/pnas.0811968106. Epub 2009 Mar 19. PMID: 19299505