TopFIND 4.0

Evidence Source

Description Imported from Merops: Cleavage (by PCSK1)/By similarity PROPEP Merops-evidence: theoretical | Merops-type: physiological | Merops-range: 21-180

Method


Experimental system

unknown

Perturbation

none

Protease inhibitor(s) used


Directness

unknown

Physiological relevance

yes

Evidence Code(s)

    inferred from in-silico analysis

Database / Laboratory

    - Lab: Steiner DF
    - DB: MEROPS

Raw data repository

Evidence for:

0

N-termini

0

C-termini


Publication(s)

Differential processing of proglucagon by the subtilisin-like prohormone convertases PC2 and PC3 to generate either glucagon or glucagon-like peptide.

Rouille Y, Martin S, Steiner DF

J Biol Chem. 1995 Nov 3;270(44):26488-96. PMID: 7592866