A3KFM7: Chromodomain-helicase-DNA-binding protein 6
| Protein names | - Chromodomain-helicase-DNA-binding protein 6 - CHD-6 - 3.6.4.12 - ATP-dependent helicase CHD6 |
|---|---|
| Gene names | Chd6 |
| Organism | Mus musculus |
| Protease Family | |
| Protease ID | |
| Chromosome location | |
| UniProt ID | A3KFM7 |
2
N-termini
2
C-termini
0
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MKMKIQKKEK QLSKLRALNH SPMSDASVNF DYKSPSPFDC SPDQGENIEE AANHCLPHKN
70 80 90 100 110 120
LYTTEEEADT LFSRKLTSHN GMEDSGGRGT GVKKKRKKKE PGEQEGTKGS KDREPKPKRK
130 140 150 160 170 180
REPKEPKEPR RAKEPKRAKE PKETKQKDGV KKPRKHREAS GTKEGKEKRS CTDYGSRTKS
190 200 210 220 230 240
KKASREQGPT PVERKKKGKR KNETTVESLE LDHSLPNPSL QSPEEPSESA DSQKRRSGRQ
250 260 270 280 290 300
VKRRKYNEDL DFKVVDDDGE TIAVLGAGRT SALSASTLAW QAEEPPEDDA NIIEKILASK
310 320 330 340 350 360
TVQEVHPGEP PFDLELFYVK YRNFSYLHCK WATMEELEKD PRIAQKIKRF RNKQAQMKHI
370 380 390 400 410 420
FTEPDEDLFN PDYIEIDRIL EVAHTKDAET GEEVTHYLVK WCSLPYEEST WELEEDVDPA
430 440 450 460 470 480
KVKEFESLQI LPEVKHVERP ASDAWQKLET SREYRNSNRL REYQLEGMNW LLFNWYNRKN
490 500 510 520 530 540
CILADEMGLG KTIQSIAFLS EIFVRGIHGP FLIIAPLSTI TNWEREFRTW TEMNAIVYHG
550 560 570 580 590 600
SQISRQMIQQ YEMVYRDAQG NPLSGVFKFH VVITTFEMIL ADCPELKKIH WSCVIIDEAH
610 620 630 640 650 660
RLKNRNCKLL EGLKLMALEH KVLLTGTPLQ NSVEELFSLL NFLEPSQFPS ETAFLEEFGD
670 680 690 700 710 720
LKTEEQVKKL QSILKPMMLR RLKDDVEKNL APKQETIIEV ELTNIQKKYY RAILEKNFSF
730 740 750 760 770 780
LTKGANQHNM PNLINTMMEL RKCCNHPYLI NGAEEKILED FRKAHSSEAS DFQLQAMIQA
790 800 810 820 830 840
AGKLVLIDKL LPKLIAGGHK VLIFSQMVRC LDILEDYLIQ RRYTYERIDG RVRGNLRQAA
850 860 870 880 890 900
IDRFCKPDSD RFVFLLCTRA GGLGINLTAA DTCIIFDSDW NPQNDLQAQA RCHRIGQSKA
910 920 930 940 950 960
VKVYRLITRN SYEREMFDKA SLKLGLDKAI LQDINRKGST NGVQQLSKME VEDLLRKGAY
970 980 990 1000 1010 1020
GALMDEEDEG SKFCEEDIDQ ILQRRTHTIT IQSEGKGSTF AKASFVASGN RTDISLDDPN
1030 1040 1050 1060 1070 1080
FWQKWAKIAE LDTEANNEKE SLVIDRPRVR KQTKHYNSFE EDELMEFSEL DSDSDERPTR
1090 1100 1110 1120 1130 1140
SRRLSDRARR YLRAECFRVE KNLLIFGWGR WKDILTHGRF KWPLNEKDME MICRALLVYC
1150 1160 1170 1180 1190 1200
VKHYKGDEKI KSFIWELITP SKDGQVQTLQ NHSGLSAPVP RGRKGKKTKN QLLLPELKNA
1210 1220 1230 1240 1250 1260
DWLATCNPEV VLHDDGYKKH LKQHCNKVLL RVRMLYYLKA EILGEAADKA FEGTPARELD
1270 1280 1290 1300 1310 1320
VLLPDIDYVE IPVDWWDAEA DKSLLIGVFK HGYERYNAMR ADPALCFLEK VGMPDEKSLS
1330 1340 1350 1360 1370 1380
AEQGVTDGTS DIPERGNIDK EDSAEDKLDG LQKQTASPSD GSDGIFGEKK DDSQAAQDGS
1390 1400 1410 1420 1430 1440
DPDKSPWPVS SALTARLRRL VTIYQRCNRK ELCRPEILGP GNQGYWVQEE VFRRTSEMDL
1450 1460 1470 1480 1490 1500
INKEAQKRWT RREQADFYRT VSSFGVVYDQ EKKAFDWTQF RIISRLDKKS DESLEHYFYS
1510 1520 1530 1540 1550 1560
FVAMCRNVCR LPAWKDDGPP DASIYVEPIT EERAAKTLYR IELLRKVREQ VLMCPQLHER
1570 1580 1590 1600 1610 1620
LQLCRPSLYL PVWWECGKHD RDLLIGTAKH GLNRTDYYIM NDPQLSFLDA YRNYAQHKRT
1630 1640 1650 1660 1670 1680
DTQAPGSLCC LYQSNSKLYE SLTYTPVSRT SESLESEPEN LMRMESRDDH LCLPEGGLPD
1690 1700 1710 1720 1730 1740
ITCENFVSKV QEVISLDHDE NLLPESLENM IYGKTGLSQE PHSFQEAPTT NTQSRKNTIT
1750 1760 1770 1780 1790 1800
ISASRNESCQ PPGIEAEITS ASSLMSSLEA GVAKMNIKNG KHLLVSISKE GEPCCSETGR
1810 1820 1830 1840 1850 1860
RPETIGHREA KCLVSPTLDT GHESGFVDLC SLSVYDPKRN FSSDQQLIDL LENKSLESKL
1870 1880 1890 1900 1910 1920
ILNQSDEEEE ENEDETLAIV ASATEKPEVL DFPKPTVNIP RGKNLSFHQD EAKKGRLEVV
1930 1940 1950 1960 1970 1980
SKTAGPQRVF PPPANQCHCK HIERWAHGLG SEDSEVEKPK AYQPDLYRSK ANNSTVEGET
1990 2000 2010 2020 2030 2040
AVIPTEPFKL KHELLKEPWK ESSEGGKSFS MYAPEGSEPK PEDMDFENKD DYEKDGTCLS
2050 2060 2070 2080 2090 2100
QDYPGKYSEE ESKSSASGIA GDLGEEAQEV RAPTIAQLLQ EKTLYSFSEW PKDRVIINRL
2110 2120 2130 2140 2150 2160
DNICHVVLKG KWPCSHQYEP SGALPTPVLS SSAGSRSSLS EPEATEHGFS NGAALAAQIQ
2170 2180 2190 2200 2210 2220
KESFLAPVFT KDEQKHRRPY EFEVERDAKA RSLEEYSATH GRPPIVLNGW HGESAIDLSC
2230 2240 2250 2260 2270 2280
SSEGSPGATS PFPVSASTPK IGAISSLQGA LGMDLSGILQ AGLIHPVTGQ IVNGSLRRDD
2290 2300 2310 2320 2330 2340
AAMRRRRGRR KHIEGGMDLI FLKEQTLQAG ILEVHEDAGQ TTLSTTHPEV PGATSSAPEP
2350 2360 2370 2380 2390 2400
TAAASSQAEK AVPSKSLLDW LRQQADYSLD VPGFGTSFSD KPKQRRPRCK EPGKLDISSL
2410 2420 2430 2440 2450 2460
GGEERVPAVP KEPGLRGFLP ESKFNHTLAE PVLRDAGPRR RGRRPRNELL KAPAIVADSP
2470 2480 2490 2500 2510 2520
SGMGPLFMNG LIAGMDLVGL QNVRNIPGIP LTGLVGFPAG FATMPTGEEV KNTLSMLPMM
2530 2540 2550 2560 2570 2580
LPGMAAVPQM FGVGGLLNTP MATTCTTTAS ASLASTKSGT SATEKSTEDK LSGHDVNTDA
2590 2600 2610 2620 2630 2640
LVDDKPGPSP FSDQSEPTIT TSSPVAFNPF LIPGVSPGLI YPSMFLSPGM GMALPAMQQA
2650 2660 2670 2680 2690 2700
RHSEMVGLET QKRKKKKTKG DSPTQEPASV CEKEPGSDQN CTESSATVSP EREHVAQARE
2710
EGLKDSNEDT N
Isoforms
- Isoform 2 of Chromodomain-helicase-DNA-binding protein 6Sequence View
10 20 30 40 50 60
MKMKIQKKEK QLSKLRALNH SPMSDASVNF DYKSPSPFDC SPDQGENIEE AANHCLPHKN
70 80 90 100 110 120
LYTTEEEADT LFSRKLTSHN GMEDSGGRGT GVKKKRKKKE PGEQEGTKGS KDREPKPKRK
130 140 150 160 170 180
REPKEPKEPR RAKEPKRAKE PKETKQKDGV KKPRKHREAS GTKEGKEKRS CTDYGSRTKS
190 200 210 220 230 240
KKASREQGPT PVERKKKGKR KNETTVESLE LDHSLPNPSL QSPEEPSESA DSQKRRSGRQ
250 260 270 280 290 300
VKRRKYNEDL DFKVVDDDGE TIAVLGAGRT SALSASTLAW QAEEPPEDDA NIIEKILASK
310 320 330 340 350 360
TVQEVHPGEP PFDLELFYVK YRNFSYLHCK WATMEELEKD PRIAQKIKRF RNKQAQMKHI
370 380 390 400 410 420
FTEPDEDLFN PDYIEIDRIL EVAHTKDAET GEEVTHYLVK WCSLPYEEST WELEEDVDPA
430 440 450 460 470 480
KVKEFESLQI LPEVKHVERP ASDAWQKLET SREYRNSNRL REYQLEGMNW LLFNWYNRKN
490 500 510 520 530 540
CILADEMGLG KTIQSIAFLS EIFVRGIHGP FLIIAPLSTI TNWEREFRTW TEMNAIVYHG
550 560 570 580 590 600
SQISRQMIQQ YEMVYRDAQG NPLSGVFKFH VVITTFEMIL ADCPELKKIH WSCVIIDEAH
610 620 630 640 650 660
RLKNRNCKLL EGLKLMALEH KVLLTGTPLQ NSVEELFSLL NFLEPSQFPS ETAFLEEFGD
670 680 690 700 710 720
LKTEEQVKKL QSILKPMMLR RLKDDVEKNL APKQETIIEV ELTNIQKKYY RAILEKNFSF
730 740 750 760 770 780
LTKGANQHNM PNLINTMMEL RKCCNHPYLI NGAEEKILED FRKAHSSEAS DFQLQAMIQA
790 800 810 820 830 840
AGKLVLIDKL LPKLIAGGHK VLIFSQMVRC LDILEDYLIQ RRYTYERIDG RVRGNLRQAA
850 860 870 880 890 900
IDRFCKPDSD RFVFLLCTRA GGLGINLTAA DTCIIFDSDW NPQNDLQAQA RCHRIGQSKA
910 920 930 940 950 960
VKVYRLITRN SYEREMFDKA SLKLGLDKAI LQDINRKGST NGVQQLSKME VEDLLRKGAY
970 980 990 1000 1010 1020
GALMDEEDEG SKFCEEDIDQ ILQRRTHTIT IQSEGKGSTF AKASFVASGN RTDISLDDPN
1030 1040 1050 1060 1070 1080
FWQKWAKIAE LDTEANNEKE SLVIDRPRVR KQTKHYNSFE EDELMEFSEL DSDSDERPTR
1090 1100 1110 1120 1130 1140
SRRLSDRARR YLRAECFRVE KNLLIFGWGR WKDILTHGRF KWPLNEKDME MICRALLVYC
1150 1160 1170 1180 1190 1200
VKHYKGDEKI KSFIWELITP SKDGQVQTLQ NHSGLSAPVP RGRKGKKTKN QLLLPELKNA
1210 1220 1230 1240 1250 1260
DWLATCNPEV VLHDDGYKKH LKQHCNKVLL RVRMLYYLKA EILGEAADKA FEGTPARELD
1270 1280 1290 1300 1310 1320
VLLPDIDYVE IPVDWWDAEA DKSLLIGVFK HGYERYNAMR ADPALCFLEK VGMPDEKSLS
1330 1340 1350 1360 1370 1380
AEQGVTDGTS DIPERGNIDK EDSAEDKLDG LQKQTASPSD GSDGIFGEKK DDSQAAQDGS
1390 1400 1410 1420 1430 1440
DPDKSPWPVS SALTARLRRL VTIYQRCNRK ELCRPEILGP GNQGYWVQEE VFRRTSEMDL
1450 1460 1470 1480 1490 1500
INKEAQKRWT RREQADFYRT VSSFGVVYDQ EKKAFDWTQF RIISRLDKKS DESLEHYFYS
1510 1520 1530 1540 1550 1560
FVAMCRNVCR LPAWKDDGPP DASIYVEPIT EERAAKTLYR IELLRKVREQ VLMCPQLHER
1570 1580 1590 1600 1610 1620
LQLCRPSLYL PVWWECGKHD RDLLIGTAKH GLNRTDYYIM NDPQLSFLDA YRNYAQHKRT
1630 1640 1650 1660 1670 1680
DTQAPGSLCC LYQSNSKLYE SLTYTPVSRT SESLESEPEN LMRMESRDDH LCLPEGGLPD
1690 1700 1710 1720 1730 1740
ITCENFVSKV QEVISLDHDE NLLPESLENM IYGKTGLSQE PHSFQEAPTT NTQSRKNTIT
1750 1760 1770 1780 1790 1800
ISASRNESCQ PPGIEAEITS ASSLMSSLEA GVAKMNIKNG KHLLVSISKE GEPCCSETGR
1810 1820 1830 1840 1850 1860
RPETIGHREA KCLVSPTLDT GHESGFVDLC SLSVYDPKRN FSSDQQLIDL LENKSLESKL
1870 1880 1890 1900 1910 1920
ILNQSDEEEE ENEDETLAIV ASATEKPEVL DFPKPTVNIP RGKNLSFHQD EAKKGRLEVV
1930 1940 1950 1960 1970 1980
SKTAGPQRVF PPPANQCHCK HIERWAHGLG SEDSEVEKPK AYQPDLYRSK ANNSTVEGET
1990 2000 2010 2020 2030 2040
AVIPTEPFKL KHELLKEPWK ESSEGGKSFS MYAPEGSEPK PEDMDFENKD DYEKDGTCLS
2050 2060 2070 2080 2090 2100
QDYPGKYSEE ESKSSASGIA GDLGEEAQEV RAPTIAQLLQ EKTLYSFSEW PKDRVIINRL
2110 2120 2130 2140 2150 2160
DNICHVVLKG KWPCSHQYEP SGALPTPVLS SSAGSRSSLS EPEATEHGFS NGAALAAQIQ
2170 2180 2190 2200 2210 2220
KESFLAPVFT KDEQKHRRPY EFEVERDAKA RSLEEYSATH GRPPIVLNGW HGESAIDLSC
2230 2240 2250 2260 2270 2280
SSEGSPGATS PFPVSASTPK IGAISSLQGA LGMDLSGILQ AGLIHPVTGQ IVNGSLRRDD
2290 2300 2310 2320 2330 2340
AAMRRRRGRR KHIEGGMDLI FLKEQTLQAG ILEVHEDAGQ TTLSTTHPEV PGATSSAPEP
2350 2360 2370 2380 2390 2400
TAAASSQAEK AVPSKSLLDW LRQQADYSLD VPGFGTSFSD KPKQRRPRCK EPGKLDISSL
2410 2420 2430 2440 2450 2460
GGEERVPAVP KEPGLRGFLP ESKFNHTLAE PVLRDAGPRR RGRRPRNELL KAPAIVADSP
2470 2480 2490 2500 2510 2520
SGMGPLFMNG LIAGMDLVGL QNVRNIPGIP LTGLVGFPAG FATMPTGEEV KNTLSMLPMM
2530 2540 2550 2560 2570 2580
LPGMAAVPQM FGVGGLLNTP MATTCTTTAS ASLASTKSGT SATEKSTEDK LSGHDVNTDA
2590 2600 2610 2620 2630 2640
LVDDKPGPSP FSDQSEPTIT TSSPVAFNPF LIPGVSPGLI YPSMFLSPGM GMALPAMQQA
2650 2660 2670 2680 2690 2700
RHSEMVGLET QKRKKKKTKG DSPTQEPASV CEKEPGSDQN CTESSATVSP EREHVAQARE
2710
EGLKDSNEDT N
Protein Neighborhood
Domains & Features
2 N-termini - 2 C-termini - 0 Cleavages - 0 Substrates
N-termini
| Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
|---|---|---|---|---|---|---|---|---|---|
| A3KFM7-1-unknown | MKMKIQ... | 1 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
| A3KFM7-1-unknown | MKMKIQ... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt70515 | |||
| A3KFM7-121-unknown | REPKEP... | 121 | inferred from electronic annotation | unknown | Ensembl | inferred from ensembl protein ENSMUSP00000117075 | |||
| A3KFM7-121-unknown | REPKEP... | 121 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt133492 |
C-termini
| Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|---|---|---|---|---|---|---|---|
| ...PRGRKG | 1184 | inferred from electronic annotation | unknown | Ensembl | inferred from ensembl protein ENSMUSP00000123240 | |||
| ...PRGRKG | 1184 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt116739 | |||
| ...NEDTN | 2711 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
| ...NEDTN | 2711 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt66133 |
Cleavages
| Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|
Substrates
| Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|