A4D126: D-ribitol-5-phosphate cytidylyltransferase {ECO:0000305}
| Protein names | - D-ribitol-5-phosphate cytidylyltransferase {ECO:0000305} - 2.7.7.40 {ECO:0000269|PubMed:26687144, ECO:0000269|PubMed:26923585, ECO:0000269|PubMed:27130732} - 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase-like protein - Isoprenoid synthase domain-containing protein {ECO:0000312|HGNC:HGNC:37276} - hISPD {ECO:0000303|PubMed:26687144} |
|---|---|
| Gene names | ISPD |
| Organism | Homo sapiens |
| Protease Family | |
| Protease ID | |
| Chromosome location | |
| UniProt ID | A4D126 |
2
N-termini
2
C-termini
0
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MEAGPPGSAR PAEPGPCLSG QRGADHTASA SLQSVAGTEP GRHPQAVAAV LPAGGCGERM
70 80 90 100 110 120
GVPTPKQFCP ILERPLISYT LQALERVCWI KDIVVAVTGE NMEVMKSIIQ KYQHKRISLV
130 140 150 160 170 180
EAGVTRHRSI FNGLKALAED QINSKLSKPE VVIIHDAVRP FVEEGVLLKV VTAAKEHGAA
190 200 210 220 230 240
GAIRPLVSTV VSPSADGCLD YSLERARHRA SEMPQAFLFD VIYEAYQQCS DYDLEFGTEC
250 260 270 280 290 300
LQLALKYCCT KAKLVEGSPD LWKVTYKRDL YAAESIIKER ISQEICVVMD TEEDNKHVGH
310 320 330 340 350 360
LLEEVLKSEL NHVKVTSEAL GHAGRHLQQI ILDQCYNFVC VNVTTSDFQE TQKLLSMLEE
370 380 390 400 410 420
SSLCILYPVV VVSVHFLDFK LVPPSQKMEN LMQIREFAKE VKERNILLYG LLISYPQDDQ
430 440 450
KLQESLRQGA IIIASLIKER NSGLIGQLLI A
Isoforms
- Isoform 2 of Isoprenoid synthase domain-containing protein - Isoform 2 of D-ribitol-5-phosphate cytidylyltransferaseSequence View
10 20 30 40 50 60
MEAGPPGSAR PAEPGPCLSG QRGADHTASA SLQSVAGTEP GRHPQAVAAV LPAGGCGERM
70 80 90 100 110 120
GVPTPKQFCP ILERPLISYT LQALERVCWI KDIVVAVTGE NMEVMKSIIQ KYQHKRISLV
130 140 150 160 170 180
EAGVTRHRSI FNGLKALAED QINSKLSKPE VVIIHDAVRP FVEEGVLLKV VTAAKEHGAA
190 200 210 220 230 240
GAIRPLVSTV VSPSADGCLD YSLERARHRA SEMPQAFLFD VIYEAYQQCS DYDLEFGTEC
250 260 270 280 290 300
LQLALKYCCT KAKLVEGSPD LWKVTYKRDL YAAESIIKER ISQEICVVMD TEEDNKHVGH
310 320 330 340 350 360
LLEEVLKSEL NHVKVTSEAL GHAGRHLQQI ILDQCYNFVC VNVTTSDFQE TQKLLSMLEE
370 380 390 400 410 420
SSLCILYPVV VVSVHFLDFK LVPPSQKMEN LMQIREFAKE VKERNILLYG LLISYPQDDQ
430 440 450
KLQESLRQGA IIIASLIKER NSGLIGQLLI A
10 20 30 40 50 60
MEAGPPGSAR PAEPGPCLSG QRGADHTASA SLQSVAGTEP GRHPQAVAAV LPAGGCGERM
70 80 90 100 110 120
GVPTPKQFCP ILERPLISYT LQALERVCWI KDIVVAVTGE NMEVMKSIIQ KYQHKRISLV
130 140 150 160 170 180
EAGVTRHRSI FNGLKALAED QINSKLSKPE VVIIHDAVRP FVEEGVLLKV VTAAKEHGAA
190 200 210 220 230 240
GAIRPLVSTV VSPSADGCLD YSLERARHRA SEMPQAFLFD VIYEAYQQCS DYDLEFGTEC
250 260 270 280 290 300
LQLALKYCCT KAKLVEGSPD LWKVTYKRDL YAAESIIKER ISQEICVVMD TEEDNKHVGH
310 320 330 340 350 360
LLEEVLKSEL NHVKVTSEAL GHAGRHLQQI ILDQCYNFVC VNVTTSDFQE TQKLLSMLEE
370 380 390 400 410 420
SSLCILYPVV VVSVHFLDFK LVPPSQKMEN LMQIREFAKE VKERNILLYG LLISYPQDDQ
430 440 450
KLQESLRQGA IIIASLIKER NSGLIGQLLI A
Protein Neighborhood
Domains & Features
2 N-termini - 2 C-termini - 0 Cleavages - 0 Substrates
N-termini
| Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
|---|---|---|---|---|---|---|---|---|---|
| A4D126-1-acetylation | MEAGPP... | 1 | acetylation- | COFRADIC | Gevaert K. | Van Damme P et al.: Complementary positional proteomics for screening substrates... | 20526345 | ||
| A4D126-1-acetylation | MEAGPP... | 1 | acetylation- | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt162353 | ||
| A4D126-1-unknown | MEAGPP... | 1 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
| A4D126-1-unknown | MEAGPP... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt78107 |
C-termini
| Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|---|---|---|---|---|---|---|---|
| ...QLLIA | 451 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
| ...QLLIA | 451 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt73725 | |||
| ...QLLIA | 451 | COFRADIC | Gevaert K. | Van Damme P et al.: Complementary positional proteomics for screening substrates... | 20526345, | |||
| ...QLLIA | 451 | COFRADIC | Gevaert K. | Van Damme P et al.: Complementary positional proteomics for screening substrates... | 20526345, |
Cleavages
| Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|
Substrates
| Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|