A7E2Y1: Myosin-7B
| Protein names | - Myosin-7B - Antigen MLAA-21 - Myosin cardiac muscle beta chain - Myosin heavy chain 7B, cardiac muscle beta isoform - Slow A MYH14 |
|---|---|
| Gene names | MYH7B |
| Organism | Homo sapiens |
| Protease Family | |
| Protease ID | |
| Chromosome location | |
| UniProt ID | A7E2Y1 |
2
N-termini
2
C-termini
0
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MSGNKRGSRA SCPHRGAECL LPWAALNLQG FQLLLLHPSA TAMMDVSELG ESARYLRQGY
70 80 90 100 110 120
QEMTKVHTIP WDGKKRVWVP DEQDAYVEAE VKSEATGGRV TVETKDQKVL MVREAELQPM
130 140 150 160 170 180
NPPRFDLLED MAMMTHLNEA SVLHNLRQRY ARWMIYTYSG LFCVTINPYK WLPVYTASVV
190 200 210 220 230 240
AAYKGKRRSD SPPHIYAVAD NAYNDMLRNR DNQSMLITGE SGAGKTVNTK RVIQYFAIVA
250 260 270 280 290 300
ALGDGPGKKA QFLATKTGGT LEDQIIEANP AMEAFGNAKT LRNDNSSRFG KFIRIHFGPS
310 320 330 340 350 360
GKLASADIDS YLLEKSRVIF QLPGERSYHV YYQILSGRKP ELQDMLLLSM NPYDYHFCSQ
370 380 390 400 410 420
GVITVDNMND GEELIATDHA MDILGFSVDE KCACYKIVGA LLHFGNMKFK QKQREEQAEA
430 440 450 460 470 480
DGTESADKAA YLMGVSSGDL LKGLLHPRVR VGNEYVTKGQ SVEQVVFAVG ALAKATYDRL
490 500 510 520 530 540
FRWLVSRINQ TLDTKLPRQF FIGVLDIAGF EIFEFNSFEQ LCINFTNEKL QQFFNQHMFV
550 560 570 580 590 600
LEQEEYKREG IDWVFIDFGL DLQPCIDLIE KPLGILSILE EECMFPKASD ASFRAKLYDN
610 620 630 640 650 660
HAGKSPNFQQ PRPDKKRKYQ AHFEVVHYAG VVPYSIVGWL EKNKDPLNET VVPIFQKSQN
670 680 690 700 710 720
RLLATLYENY AGSCSTEPPK SGVKEKRKKA ASFQTVSQLH KENLNKLMTN LRATQPHFVR
730 740 750 760 770 780
CIVPNENKTP GVMDAFLVLH QLRCNGVLEG IRICRQGFPN RLLYTDFRQR YRILNPSAIP
790 800 810 820 830 840
DDTFMDSRKA TEKLLGSLDL DHTQYQFGHT KVFFKAGLLG VLEELRDQRL AKVLTLLQAR
850 860 870 880 890 900
SRGRLMRLEY QRLLGGRDAL FTIQWNIRAF NAVKNWSWMK LFFKMKPLLR SAQAEEELAA
910 920 930 940 950 960
LRAELRGLRG ALAAAEAKRQ ELEETHVSIT QEKNDLALQL QAEQDNLADA EERCHLLIKS
970 980 990 1000 1010 1020
KVQLEGKVKE LSERLEDEEE VNADLAARRR KLEDECTELK KDIDDLELTL AKAEKEKQAT
1030 1040 1050 1060 1070 1080
ENKVKNLTEE MAALDESVAR LTKEKKALQE AHQQALGDLQ AEEDRVSALT KAKLRLEQQV
1090 1100 1110 1120 1130 1140
EDLECSLEQE KKLRMDTERA KRKLEGDLKL TQESVADAAQ DKQQLEEKLK KKDSELSQLS
1150 1160 1170 1180 1190 1200
LRVEDEQLLG AQMQKKIKEL QARAEELEEE LEAERAARAR VEKQRAEAAR ELEELSERLE
1210 1220 1230 1240 1250 1260
EAGGASAGQR EGCRKREAEL GRLRRELEEA ALRHEATVAA LRRKQAEGAA ELGEQVDSLQ
1270 1280 1290 1300 1310 1320
RVRQKLEKEK SELRMEVDDL AANVETLTRA KASAEKLCRT YEDQLSEAKI KVEELQRQLA
1330 1340 1350 1360 1370 1380
DASTQRGRLQ TESGELSRLL EEKECLISQL SRGKALAAQS LEELRRQLEE ESKAKSALAH
1390 1400 1410 1420 1430 1440
AVQALRHDCD LLREQHEEEA EAQAELQRLL SKANAEVAQW RSKYEADAIQ RTEELEEAKK
1450 1460 1470 1480 1490 1500
KLALRLQEAE EGVEAANAKC SSLEKAKLRL QTESEDVTLE LERATSAAAA LDKKQRHLER
1510 1520 1530 1540 1550 1560
ALEERRRQEE EMQRELEAAQ RESRGLGTEL FRLRHGHEEA LEALETLKRE NKNLQEEISD
1570 1580 1590 1600 1610 1620
LTDQVSLSGK SIQELEKTKK ALEGEKSEIQ AALEEAEGAL ELEETKTLRI QLELSQVKAE
1630 1640 1650 1660 1670 1680
VDRKLAEKDE ECANLRRNHQ RAVESLQASL DAETRARNEA LRLKKKMEGD LNDLELQLGH
1690 1700 1710 1720 1730 1740
ATRQATEAQA ATRLMQAQLK EEQAGRDEEQ RLAAELHEQA QALERRASLL AAELEELRAA
1750 1760 1770 1780 1790 1800
LEQGERSRRL AEQELLEATE RLNLLHSQNT GLLNQKKKLE ADLAQLSGEV EEAAQERREA
1810 1820 1830 1840 1850 1860
EEKAKKAITD AAMMAEELKK EQDTSAHLER MKKTLEQTVR ELQARLEEAE QAALRGGKKQ
1870 1880 1890 1900 1910 1920
VQKLEAKVRE LEAELDAEQK KHAEALKGVR KHERRVKELA YQAEEDRKNL ARMQDLVDKL
1930 1940 1950 1960 1970 1980
QSKVKSYKRQ FEEAEQQANT NLAKYRKAQH ELDDAEERAD MAETQANKLR ARTRDALGPK
HKE
Isoforms
- Isoform 2 of Myosin-7B - Isoform 3 of Myosin-7BSequence View
10 20 30 40 50 60
MSGNKRGSRA SCPHRGAECL LPWAALNLQG FQLLLLHPSA TAMMDVSELG ESARYLRQGY
70 80 90 100 110 120
QEMTKVHTIP WDGKKRVWVP DEQDAYVEAE VKSEATGGRV TVETKDQKVL MVREAELQPM
130 140 150 160 170 180
NPPRFDLLED MAMMTHLNEA SVLHNLRQRY ARWMIYTYSG LFCVTINPYK WLPVYTASVV
190 200 210 220 230 240
AAYKGKRRSD SPPHIYAVAD NAYNDMLRNR DNQSMLITGE SGAGKTVNTK RVIQYFAIVA
250 260 270 280 290 300
ALGDGPGKKA QFLATKTGGT LEDQIIEANP AMEAFGNAKT LRNDNSSRFG KFIRIHFGPS
310 320 330 340 350 360
GKLASADIDS YLLEKSRVIF QLPGERSYHV YYQILSGRKP ELQDMLLLSM NPYDYHFCSQ
370 380 390 400 410 420
GVITVDNMND GEELIATDHA MDILGFSVDE KCACYKIVGA LLHFGNMKFK QKQREEQAEA
430 440 450 460 470 480
DGTESADKAA YLMGVSSGDL LKGLLHPRVR VGNEYVTKGQ SVEQVVFAVG ALAKATYDRL
490 500 510 520 530 540
FRWLVSRINQ TLDTKLPRQF FIGVLDIAGF EIFEFNSFEQ LCINFTNEKL QQFFNQHMFV
550 560 570 580 590 600
LEQEEYKREG IDWVFIDFGL DLQPCIDLIE KPLGILSILE EECMFPKASD ASFRAKLYDN
610 620 630 640 650 660
HAGKSPNFQQ PRPDKKRKYQ AHFEVVHYAG VVPYSIVGWL EKNKDPLNET VVPIFQKSQN
670 680 690 700 710 720
RLLATLYENY AGSCSTEPPK SGVKEKRKKA ASFQTVSQLH KENLNKLMTN LRATQPHFVR
730 740 750 760 770 780
CIVPNENKTP GVMDAFLVLH QLRCNGVLEG IRICRQGFPN RLLYTDFRQR YRILNPSAIP
790 800 810 820 830 840
DDTFMDSRKA TEKLLGSLDL DHTQYQFGHT KVFFKAGLLG VLEELRDQRL AKVLTLLQAR
850 860 870 880 890 900
SRGRLMRLEY QRLLGGRDAL FTIQWNIRAF NAVKNWSWMK LFFKMKPLLR SAQAEEELAA
910 920 930 940 950 960
LRAELRGLRG ALAAAEAKRQ ELEETHVSIT QEKNDLALQL QAEQDNLADA EERCHLLIKS
970 980 990 1000 1010 1020
KVQLEGKVKE LSERLEDEEE VNADLAARRR KLEDECTELK KDIDDLELTL AKAEKEKQAT
1030 1040 1050 1060 1070 1080
ENKVKNLTEE MAALDESVAR LTKEKKALQE AHQQALGDLQ AEEDRVSALT KAKLRLEQQV
1090 1100 1110 1120 1130 1140
EDLECSLEQE KKLRMDTERA KRKLEGDLKL TQESVADAAQ DKQQLEEKLK KKDSELSQLS
1150 1160 1170 1180 1190 1200
LRVEDEQLLG AQMQKKIKEL QARAEELEEE LEAERAARAR VEKQRAEAAR ELEELSERLE
1210 1220 1230 1240 1250 1260
EAGGASAGQR EGCRKREAEL GRLRRELEEA ALRHEATVAA LRRKQAEGAA ELGEQVDSLQ
1270 1280 1290 1300 1310 1320
RVRQKLEKEK SELRMEVDDL AANVETLTRA KASAEKLCRT YEDQLSEAKI KVEELQRQLA
1330 1340 1350 1360 1370 1380
DASTQRGRLQ TESGELSRLL EEKECLISQL SRGKALAAQS LEELRRQLEE ESKAKSALAH
1390 1400 1410 1420 1430 1440
AVQALRHDCD LLREQHEEEA EAQAELQRLL SKANAEVAQW RSKYEADAIQ RTEELEEAKK
1450 1460 1470 1480 1490 1500
KLALRLQEAE EGVEAANAKC SSLEKAKLRL QTESEDVTLE LERATSAAAA LDKKQRHLER
1510 1520 1530 1540 1550 1560
ALEERRRQEE EMQRELEAAQ RESRGLGTEL FRLRHGHEEA LEALETLKRE NKNLQEEISD
1570 1580 1590 1600 1610 1620
LTDQVSLSGK SIQELEKTKK ALEGEKSEIQ AALEEAEGAL ELEETKTLRI QLELSQVKAE
1630 1640 1650 1660 1670 1680
VDRKLAEKDE ECANLRRNHQ RAVESLQASL DAETRARNEA LRLKKKMEGD LNDLELQLGH
1690 1700 1710 1720 1730 1740
ATRQATEAQA ATRLMQAQLK EEQAGRDEEQ RLAAELHEQA QALERRASLL AAELEELRAA
1750 1760 1770 1780 1790 1800
LEQGERSRRL AEQELLEATE RLNLLHSQNT GLLNQKKKLE ADLAQLSGEV EEAAQERREA
1810 1820 1830 1840 1850 1860
EEKAKKAITD AAMMAEELKK EQDTSAHLER MKKTLEQTVR ELQARLEEAE QAALRGGKKQ
1870 1880 1890 1900 1910 1920
VQKLEAKVRE LEAELDAEQK KHAEALKGVR KHERRVKELA YQAEEDRKNL ARMQDLVDKL
1930 1940 1950 1960 1970 1980
QSKVKSYKRQ FEEAEQQANT NLAKYRKAQH ELDDAEERAD MAETQANKLR ARTRDALGPK
HKE
10 20 30 40 50 60
MSGNKRGSRA SCPHRGAECL LPWAALNLQG FQLLLLHPSA TAMMDVSELG ESARYLRQGY
70 80 90 100 110 120
QEMTKVHTIP WDGKKRVWVP DEQDAYVEAE VKSEATGGRV TVETKDQKVL MVREAELQPM
130 140 150 160 170 180
NPPRFDLLED MAMMTHLNEA SVLHNLRQRY ARWMIYTYSG LFCVTINPYK WLPVYTASVV
190 200 210 220 230 240
AAYKGKRRSD SPPHIYAVAD NAYNDMLRNR DNQSMLITGE SGAGKTVNTK RVIQYFAIVA
250 260 270 280 290 300
ALGDGPGKKA QFLATKTGGT LEDQIIEANP AMEAFGNAKT LRNDNSSRFG KFIRIHFGPS
310 320 330 340 350 360
GKLASADIDS YLLEKSRVIF QLPGERSYHV YYQILSGRKP ELQDMLLLSM NPYDYHFCSQ
370 380 390 400 410 420
GVITVDNMND GEELIATDHA MDILGFSVDE KCACYKIVGA LLHFGNMKFK QKQREEQAEA
430 440 450 460 470 480
DGTESADKAA YLMGVSSGDL LKGLLHPRVR VGNEYVTKGQ SVEQVVFAVG ALAKATYDRL
490 500 510 520 530 540
FRWLVSRINQ TLDTKLPRQF FIGVLDIAGF EIFEFNSFEQ LCINFTNEKL QQFFNQHMFV
550 560 570 580 590 600
LEQEEYKREG IDWVFIDFGL DLQPCIDLIE KPLGILSILE EECMFPKASD ASFRAKLYDN
610 620 630 640 650 660
HAGKSPNFQQ PRPDKKRKYQ AHFEVVHYAG VVPYSIVGWL EKNKDPLNET VVPIFQKSQN
670 680 690 700 710 720
RLLATLYENY AGSCSTEPPK SGVKEKRKKA ASFQTVSQLH KENLNKLMTN LRATQPHFVR
730 740 750 760 770 780
CIVPNENKTP GVMDAFLVLH QLRCNGVLEG IRICRQGFPN RLLYTDFRQR YRILNPSAIP
790 800 810 820 830 840
DDTFMDSRKA TEKLLGSLDL DHTQYQFGHT KVFFKAGLLG VLEELRDQRL AKVLTLLQAR
850 860 870 880 890 900
SRGRLMRLEY QRLLGGRDAL FTIQWNIRAF NAVKNWSWMK LFFKMKPLLR SAQAEEELAA
910 920 930 940 950 960
LRAELRGLRG ALAAAEAKRQ ELEETHVSIT QEKNDLALQL QAEQDNLADA EERCHLLIKS
970 980 990 1000 1010 1020
KVQLEGKVKE LSERLEDEEE VNADLAARRR KLEDECTELK KDIDDLELTL AKAEKEKQAT
1030 1040 1050 1060 1070 1080
ENKVKNLTEE MAALDESVAR LTKEKKALQE AHQQALGDLQ AEEDRVSALT KAKLRLEQQV
1090 1100 1110 1120 1130 1140
EDLECSLEQE KKLRMDTERA KRKLEGDLKL TQESVADAAQ DKQQLEEKLK KKDSELSQLS
1150 1160 1170 1180 1190 1200
LRVEDEQLLG AQMQKKIKEL QARAEELEEE LEAERAARAR VEKQRAEAAR ELEELSERLE
1210 1220 1230 1240 1250 1260
EAGGASAGQR EGCRKREAEL GRLRRELEEA ALRHEATVAA LRRKQAEGAA ELGEQVDSLQ
1270 1280 1290 1300 1310 1320
RVRQKLEKEK SELRMEVDDL AANVETLTRA KASAEKLCRT YEDQLSEAKI KVEELQRQLA
1330 1340 1350 1360 1370 1380
DASTQRGRLQ TESGELSRLL EEKECLISQL SRGKALAAQS LEELRRQLEE ESKAKSALAH
1390 1400 1410 1420 1430 1440
AVQALRHDCD LLREQHEEEA EAQAELQRLL SKANAEVAQW RSKYEADAIQ RTEELEEAKK
1450 1460 1470 1480 1490 1500
KLALRLQEAE EGVEAANAKC SSLEKAKLRL QTESEDVTLE LERATSAAAA LDKKQRHLER
1510 1520 1530 1540 1550 1560
ALEERRRQEE EMQRELEAAQ RESRGLGTEL FRLRHGHEEA LEALETLKRE NKNLQEEISD
1570 1580 1590 1600 1610 1620
LTDQVSLSGK SIQELEKTKK ALEGEKSEIQ AALEEAEGAL ELEETKTLRI QLELSQVKAE
1630 1640 1650 1660 1670 1680
VDRKLAEKDE ECANLRRNHQ RAVESLQASL DAETRARNEA LRLKKKMEGD LNDLELQLGH
1690 1700 1710 1720 1730 1740
ATRQATEAQA ATRLMQAQLK EEQAGRDEEQ RLAAELHEQA QALERRASLL AAELEELRAA
1750 1760 1770 1780 1790 1800
LEQGERSRRL AEQELLEATE RLNLLHSQNT GLLNQKKKLE ADLAQLSGEV EEAAQERREA
1810 1820 1830 1840 1850 1860
EEKAKKAITD AAMMAEELKK EQDTSAHLER MKKTLEQTVR ELQARLEEAE QAALRGGKKQ
1870 1880 1890 1900 1910 1920
VQKLEAKVRE LEAELDAEQK KHAEALKGVR KHERRVKELA YQAEEDRKNL ARMQDLVDKL
1930 1940 1950 1960 1970 1980
QSKVKSYKRQ FEEAEQQANT NLAKYRKAQH ELDDAEERAD MAETQANKLR ARTRDALGPK
HKE
Protein Neighborhood
Domains & Features
2 N-termini - 2 C-termini - 0 Cleavages - 0 Substrates
N-termini
| Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
|---|---|---|---|---|---|---|---|---|---|
| A7E2Y1-1-unknown | MSGNKR... | 1 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
| A7E2Y1-1-unknown | MSGNKR... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt81965 | |||
| A7E2Y1-1826-unknown | AHLERM... | 1826 | inferred from electronic annotation | unknown | Ensembl | inferred from ensembl protein ENSP00000395858 | |||
| A7E2Y1-1826-unknown | AHLERM... | 1826 | inferred from electronic annotation | unknown | Ensembl | inferred from ensembl protein ENSP00000409103 | |||
| A7E2Y1-1826-unknown | AHLERM... | 1826 | inferred from electronic annotation | unknown | Ensembl | inferred from ensembl protein ENSP00000391939 | |||
| A7E2Y1-1826-unknown | AHLERM... | 1826 | inferred from electronic annotation | unknown | Ensembl | inferred from ensembl protein ENSP00000412594 | |||
| A7E2Y1-1826-unknown | AHLERM... | 1826 | inferred from electronic annotation | unknown | Ensembl | inferred from ensembl protein ENSP00000396368 | |||
| A7E2Y1-1826-unknown | AHLERM... | 1826 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt130996 |
C-termini
| Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|---|---|---|---|---|---|---|---|
| ...LPVYTA | 176 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt77583 | |||
| ...QANTNL | 1941 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
| ...QANTNL | 1941 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt77584 |
Cleavages
| Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|
Substrates
| Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|