E9Q555: E3 ubiquitin-protein ligase RNF213
Protein names | - E3 ubiquitin-protein ligase RNF213 - 2.3.2.27 {ECO:0000250|UniProtKB:Q63HN8} - 3.6.4.- {ECO:0000250|UniProtKB:Q63HN8} - Mysterin {ECO:0000303|PubMed:26126547} - RING finger protein 213 {ECO:0000305} - RING-type E3 ubiquitin transferase RNF213 {ECO:0000305} |
---|---|
Gene names | Rnf213 |
Organism | Mus musculus |
Protease Family | |
Protease ID | |
Chromosome location | |
UniProt ID | E9Q555 |
2
N-termini
1
C-termini
0
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MECPQCGHVS SEKAPKFCSE CGQKLPSAAT VQGDLKNDNT LVVSSTPEGK TEQGAVLREE
70 80 90 100 110 120
EVLLSSTDPG KELEKPEESD SNASWTTQMS KKEKRRRKRQ GTISSSEAPS SGLWSLDMPP
130 140 150 160 170 180
SPGSHNSALP QNQAQQGGAA SQPGHPLDTE NMPMEDGFVH TEGSGSPLQG QAAERTDAQS
190 200 210 220 230 240
NLAPSDLAEV KDLNTSKPSV DKGLPLDGGP ALSAFKGHPK MTDASQKAPL PESKGETSGQ
250 260 270 280 290 300
EKKVPPIDAA ASPVKTAGKE TGEDVRKPKP SPVSPVASKH GDQEAELKGK LATPVRKSNE
310 320 330 340 350 360
GGNTQPEDQR KPGEGRNFAA AVKTQQAAAP QQAAAPEPTS AFNPRDTVTV YFHAIVSRHF
370 380 390 400 410 420
GFNPEEHKVY VRGGEGLGQK GWTDACEMYC TQDLHDLGSL VEGKMDIPRQ SLDKPIPYKY
430 440 450 460 470 480
VIHRGGSSKD TVEYEFIYEQ AQKKGEHVNR CLRVVSTSLG NGDWHQYDDI ICMRSTGFFQ
490 500 510 520 530 540
QAKNRILDST RKELLKGKKQ AAVVMLDRIF SVLQPWSDIN LQSFMTQFLQ FYSVVREPMI
550 560 570 580 590 600
HDGRARKWTS LQYEEKEVWT NLWEHVKKQM APFLEGKSGE SLPADCPVRS KLTLGLSILF
610 620 630 640 650 660
MVEAAEFTVP KKDLDSLCYL LIPSAGSPEA LHSDLSPVLR IRQRWRIYLT NLCLRCIDER
670 680 690 700 710 720
CDRWLGILPL LHTCMQKSPP KKNSKSQPED TWAGLEGISF SEFRDKAPTR SQPLQFMQSK
730 740 750 760 770 780
MALLRVDEYL FRSWLSVVPL ESLSSYLENS IDYLSDVPVR VLDCLQGISY RLPGLRKISN
790 800 810 820 830 840
QNMKKDVENV FKMLMHLVDI YQHRIFGENL LQIYLTECLT LHETVCNITA NHQFFEIPAL
850 860 870 880 890 900
SAELICKLLE LSPPGHTDEG LPEKSYEDLV TSTLQEALAT TRNWLRSLFK SRMLSISSAY
910 920 930 940 950 960
VRLTYSEEMA VWRRLVEIGF PEKHGWKGSL LGDMEGRLKQ EPPRLQISFF CSSQCRDGGL
970 980 990 1000 1010 1020
HDSVSRSFEK CVIEAVSSAC QSQTSVLEGL SCQDLQKFGT LLSAVITKSW PVHNGEPVFD
1030 1040 1050 1060 1070 1080
VDEIFKYLLK WPDVRQLFEL CGTNEKIIDN ITEEGRQLMA TAESVFQKVA GELENGTIVV
1090 1100 1110 1120 1130 1140
GQLELILEHQ SQFLDIWNLN RRRLPSQEKA CDVRSLLKRR RDDLLFLKQE KRYVESLLRQ
1150 1160 1170 1180 1190 1200
LGRVKHLVQV DFGNIEIIHS QDLSNKKLNE AVIKLPNSSS YKRETHYCLS PDIREMASKL
1210 1220 1230 1240 1250 1260
DSLKDSHIFQ DFWQETAESL NTLDKDPREL KVSLPEVLEY LYNPCYDNFY TLYENLKSGK
1270 1280 1290 1300 1310 1320
ITFAEVDAIF KDFVDKYDEL KNDLKFMCTM NPQDQKGWIS ERVGQIKEYH TLHQAVSSAK
1330 1340 1350 1360 1370 1380
VILQVRRALG VTGDFSVLNP LLNFADSFED FGNEKLDQIS PQFIKAKQLL QDISEPRQRC
1390 1400 1410 1420 1430 1440
LEELARQTEL VAWLHKALED INELKVFVDL ASISAGENDI DVDRVACFHD AVQGYASLLY
1450 1460 1470 1480 1490 1500
KMDERTNFSD FMNHLQELWR ALDNDQHLPD KLKDSARNLE WLKTVKESHG SVELSSLSLA
1510 1520 1530 1540 1550 1560
TAINSRGVYV IEAPKDGQKI SPDTVLRLLL PDGHGYPEAL RTYSTEELKE LLNKLMLMSG
1570 1580 1590 1600 1610 1620
KKDHNSNTEV EKFSEVFSNM QRLVHVFIKL HCAGNMLFRT WTAKVYCCPD GGIFMNFGLE
1630 1640 1650 1660 1670 1680
LLSQLTEKGD VIQLLGALCR QMEDFLDNWK TVVAQKRAEH FYLNFYTAEQ LVYLSSELRK
1690 1700 1710 1720 1730 1740
PRPSEAALMM LSFIKGKCTV QDLVQATSAC ESKADRYCLR EVMKKLPQQL LSEPSLMGKL
1750 1760 1770 1780 1790 1800
QVIMMQSLVY MSAFLPHCLD LDALGRCLAH LATMGGTPVE RPLPKGLQAG QPNLILCGHS
1810 1820 1830 1840 1850 1860
EVLPAALAIY MQAPRQPLPT FDEVLLCTPA TTIEEVELLL RRCLTSGSQG HKVYSLLFAD
1870 1880 1890 1900 1910 1920
QLSYEVGCQA EEFFQSLCTR AHREDYQLVI LCDAAREHCY IPSTFSQYKV PLVPQAPLPN
1930 1940 1950 1960 1970 1980
IQAYLQSHYQ VPKRLLSAAT VFRDGLCVGI VTSERAGVGK SLYVNTLHTK LKAKLRDETV
1990 2000 2010 2020 2030 2040
PLKIIRLTEP HLDENQVLSA LLPFLKEKYQ KMPVIFHIDI STSVQTGIPI FLFKLLILQY
2050 2060 2070 2080 2090 2100
LMDINGKIWR RSPGHLYLVE IPQGLSVQPK RSSKLNARAP LFKFLDLFPK VTCRPPKEVI
2110 2120 2130 2140 2150 2160
DMELTPERSH TDPAMDPVEF CSEAFQRPYQ YLKRFHQQQN LDTFQYEKGS VEGSPEECLQ
2170 2180 2190 2200 2210 2220
HFLIYCGLIN PSWSELRNFA WFLNCQLKDC EASIFCKSAF TGDTLRGFKN FVVTFMILMA
2230 2240 2250 2260 2270 2280
RDFATPTLHT SDQSPGRQSV TIGEVVEEDL APFSLRKRWE SEPHPYVFFN GDHMTMTFIG
2290 2300 2310 2320 2330 2340
FHLETNNNGY VDAINPSNGK VIKKDVMTKE LFDGLRLQRV PFNIDFDNLP RYEKLERLCL
2350 2360 2370 2380 2390 2400
ALGIEWPIDP DETYELTTDN MLKILAIEMR FRCGIPVIIM GETGCGKTRL IKFLSDLKRG
2410 2420 2430 2440 2450 2460
SVEAETMKLV KVHGGTTPSM IYSKVKEAER TAFSNKAQHK LDTILFFDEA NTTEAVSCIK
2470 2480 2490 2500 2510 2520
EILCDRTVDG EHLHEDSGLH IIAACNPYRK HSQEMILRLE SAGLGYRVSA EETADRLGSI
2530 2540 2550 2560 2570 2580
PLRQLVYRVH ALPPSLIPLV WDFGQLNDSA EKLYIQQIVQ RLVDSVSVNP SETCVIADVL
2590 2600 2610 2620 2630 2640
SASQMFMRKR ENECGFVSLR DVERCVKVFR WFHDHSDMLL KELDKFLHES SDSTHTFERD
2650 2660 2670 2680 2690 2700
PVLWSLVMAI GVCYHASLEE KASYRTAIAR CFPKPYNSSR AILDEVTHVQ DLFLRGAPIR
2710 2720 2730 2740 2750 2760
TNIARNLALK ENVFMMVICI ELKIPLFLVG KPGSSKSLAK IIVADAMQGQ AAFSELFRCL
2770 2780 2790 2800 2810 2820
KQVHLVSFQC SPHSTPQGII STFKQCARFQ QGKDLGQYVS VVVLDEVGLA EDSPKMPLKT
2830 2840 2850 2860 2870 2880
LHPLLEDGCI EDDPAPYKKV GFVGISNWAL DPAKMNRGIF VSRGSPNEKE LIESAEGICS
2890 2900 2910 2920 2930 2940
SDRLVQDKIR GYFAPFAKAY ETVCQKQDKE FFGLRDYYSL IKMVFAKAKA SKRGLSPQDI
2950 2960 2970 2980 2990 3000
THAVLRNFSG KDNIQALSIF TASLPEARYK EEVSTVELIK QNIYPGPQAS SRGLDGAESR
3010 3020 3030 3040 3050 3060
YLLVLTRNYV ALQILQQTFF EGQQPEIIFG SSFPQDQEYT QICRNINRVK ICMETGKMVV
3070 3080 3090 3100 3110 3120
LLNLQNLYES LYDALNQYYV YLGGQKYVDL GLGTHRVKCR VHTAFRLIVI EEKDVVYKQF
3130 3140 3150 3160 3170 3180
PVPLINRLEK HYLDMNTVLQ PWQKSIVQEL QQWAHEFADV KADQFIARHK YSPADVFIGY
3190 3200 3210 3220 3230 3240
HSDACASVVL QAVERQGCRD LTEELYRKVS EEARSILLDC ATPDAVVRLS GSSLGSFTAK
3250 3260 3270 3280 3290 3300
QLSQEYYYAQ QHNSFVDFLQ AHLRMTHHEC RAVFTEITTF SRLLTGNDCD VLASELRGLA
3310 3320 3330 3340 3350 3360
SKPVVLSLQQ YDTEYSFLKD VRSWLTNPGK RKVLVIQADF DDGTRSAQLV ASAKYTAINE
3370 3380 3390 3400 3410 3420
INKTQGTKDF VFVYFVTKLS RMGSGTSYVG FHGGLWRSVH IDDLRRSTIM ASDVTKLQNV
3430 3440 3450 3460 3470 3480
TISQLFKPED KPEQEEMEIE TSQSKELAEE QMEVEDSEEM KKASDPRSCD CSQFLDTTRL
3490 3500 3510 3520 3530 3540
VQSCVQGAVG MLRDQNESCA RNMRRVTILL DLLNEDNTRN ASFLRESKMR LHVLLNKQEE
3550 3560 3570 3580 3590 3600
NQVRSLKEWV TREAANQDAL QEAGTFRHTL WKRVQDVVTP ILASMIAHID RDGNLELLAQ
3610 3620 3630 3640 3650 3660
PDSPAWVQDL WMFIYSDIKF LNISLVLNNT RSNSEMSFIL VQSHMNLLKD AYNAVPFSWR
3670 3680 3690 3700 3710 3720
IRDYLEELWV QAQYITDTEG LSKKFVEIFQ KTPLGVFLAQ FPVAQQQKLL QSYLKDFLLL
3730 3740 3750 3760 3770 3780
TMKVSSREEL MFLQMALWSC LRELQEASGT PDETYKFPLS LPWVHLAFQH FRTRLQNFSR
3790 3800 3810 3820 3830 3840
ILTIHPQVLS SLSQAAEKHS LAGCEMTLDA FAAMACAEML KGDLLKPSPK AWLQLVKNLS
3850 3860 3870 3880 3890 3900
TPLELVCSEG YLCDSGSMTR SVIQEVRALW NRIFSIALFV EHVLLGTESH IPELSPLVTT
3910 3920 3930 3940 3950 3960
YVSLLDKCLE EDSNLKTCRP FVAVMTTLCD CKDKASKKFS RFGIQPCFIC HGDAQDPVCL
3970 3980 3990 4000 4010 4020
PCDHVYCLRC IQTWLIPGQM MCPYCLTDLP DKFSPTVSQD HRKAIEKHAQ FRHMCNSFFV
4030 4040 4050 4060 4070 4080
DLVSTMCFKD NTPPEKSVID TLLSLLFVQK ELLRDASQKH REHTKSLSPF DDVVDQTPVI
4090 4100 4110 4120 4130 4140
RSVLLKLLLK YSFHEVKDYI QNYLTQLEKK AFLTEDKTEL YLLFISCLED SVHQKTSAGC
4150 4160 4170 4180 4190 4200
RNLEQVLREE GHFLRTYSPG LQGQEPVRIA SVEYLQEVAR VRLCLDLAAD FLSELQEGSE
4210 4220 4230 4240 4250 4260
LAEDKRRFLK HVEEFCTRVN NDWHRVYLVR KLSSQRGMEF VQSFSKQGHP CQWVFPRKVI
4270 4280 4290 4300 4310 4320
AQQVRNRKDH VSLMDRYLVH GNEYKAVRDA TAKAVLECKT LDIGNALMAC RSPKPQQTAY
4330 4340 4350 4360 4370 4380
LLLALYTEVA ALYRSPNGSL HPEAKQLEAV NKFIKESKIL SDPNIRCFAR SLVDNTLPLL
4390 4400 4410 4420 4430 4440
KIRSANSILK GTVTEMAVHV ATILLCGHNQ ILKPLRNLAF YPVNMANAFL PTMPEDLLVH
4450 4460 4470 4480 4490 4500
ARTWRGLENV TWYTCPRGHP CSVGECGRPM QESTCLDCGL PVGGLNHTPH EGFSAIRNNE
4510 4520 4530 4540 4550 4560
DRTQTGHVLG SPQSSGVAEV SDRGQSPVVF ILTRLLTHLA MLVGATHNPQ ALTVIIKPWV
4570 4580 4590 4600 4610 4620
QDPQGFLQQH IQRDLEQLTK MLGRSADETI HVVHLILSSL LRVQSHGVLN FNAELSTKGC
4630 4640 4650 4660 4670 4680
RNNWEKHFET LLLRELKHLD KNLPAINALI SQDERISSNP VTKIIYGDPA TFLPHLPQKS
4690 4700 4710 4720 4730 4740
IIHCSKIWSC RRKITVEYLQ HIVEQKNGKE TVPVLWHFLQ KEAELRLVKF LPEILALQRD
4750 4760 4770 4780 4790 4800
LVKQFQNVSR VEYSSIRGFI HSHSSDGLRK LLHDRITIFL STWNALRRSL ETNGEIKLPK
4810 4820 4830 4840 4850 4860
DYCCSDLDLD AEFEVILPRR QGLGLCGTAL VSYLISLHNN MVYTVQKFSN EDNSYSVDIS
4870 4880 4890 4900 4910 4920
EVADLHVISY EVERDLNPLI LSNCQYQVQQ GGETSQEFDL EKIQRQISSR FLQGKPRLTL
4930 4940 4950 4960 4970 4980
KGIPTLVYRR DWNYEHLFMD IKNKMAQSSL PNLAISTISG QLQSYSDACE ALSIIEITLG
4990 5000 5010 5020 5030 5040
FLSTAGGDPG MDLNVYIEEV LRMCDQTAQV LKAFSRCQLR HIIALWQFLS AHKSEQRLRL
5050 5060 5070 5080 5090 5100
NKELFREIDV QYKEELSTQH QRLLGTFLNE AGLDAFLLEL HEMIVLKLKG PRAANSFNPN
5110 5120 5130 5140 5150
WSLKDTLVSY METKDSDILS EVESQFPEEI LMSSCISVWK IAATRKWDRQ SR
Isoforms
Sequence View
Protein Neighborhood
Domains & Features
2 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates
N-termini
Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
---|---|---|---|---|---|---|---|---|---|
E9Q555-1-unknown | MECPQC... | 1 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
E9Q555-4839-unknown | NNMVYT... | 4839 | inferred from electronic annotation | unknown | Ensembl | inferred from ensembl protein ENSMUSP00000130027 |
C-termini
Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
...KWDRQS | 5150 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot |
Cleavages
Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
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Substrates
Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|