TopFIND 4.0

G3X9K3: Brefeldin A-inhibited guanine nucleotide-exchange protein 1

General Information

Protein names
- Brefeldin A-inhibited guanine nucleotide-exchange protein 1
- BIG1
- Brefeldin A-inhibited GEP 1
- ADP-ribosylation factor guanine nucleotide-exchange factor 1
Gene names Arfgef1
Organism Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID G3X9K3

1

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MYEGKKTKNM FLTRALEKIL ADKEVKKAHH SQLRKACEVA LEEIKVETEK QSPPHGEAKA 
        70         80         90        100        110        120 
GSGTLPPVKS KTNFIEADKY FLPFELACQS KCPRIVSTSL DCLQKLIAYG HLTGRAPDST 
       130        140        150        160        170        180 
TPGKKLIDRI IETICGCFQG PQTDEGVQLQ IIKALLTAVT SQHIEIHEGT VLQAVRTCYN 
       190        200        210        220        230        240 
IYLASKNLIN QTTAKATLTQ MLNVIFARME NQALQEAKQM ERERHRQQQH LLQSPVSHHE 
       250        260        270        280        290        300 
PESPHLRYLP PQTVDHINQE HEGDLEPQTH DVDKSLQDDT EPENGSDISS AENEQTEADQ 
       310        320        330        340        350        360 
ATAAETLSKN DILYDGDYEE KPLDIVQSIV EEMVNIIVGD MGEGMAISAS TEGNTGTVED 
       370        380        390        400        410        420 
GSDSENIQAN GIPGTPISVA YTPSLPDDRL SVSSNDTQES GNSSGPSPGA KFSHILQKDA 
       430        440        450        460        470        480 
FLVFRSLCKL SMKPLSDGPP DPKSHELRSK ILSLQLLLSI LQNAGPVFRT NEMFINAIKQ 
       490        500        510        520        530        540 
YLCVALSKNG VSSVPEVFEL SLSIFLTLLS NFKTHLKMQI EVFFKEIFLY ILETSTSSFD 
       550        560        570        580        590        600 
HKWMVIQTLT RICADAQSVV DIYVNYDCDL NAANIFERLV NDLSKIAQGR GSQELGMSNV 
       610        620        630        640        650        660 
QELSLRKKGL ECLVSILKCM VEWSKDQYVN PNSQTTLGQE KPSEQEISEV KHPETINRYG 
       670        680        690        700        710        720 
SLNSLESTSS SGIGSYSTQM SGTDNPEQFE VLKQQKEIIE QGIDLFNKKP KRGIQYLQEQ 
       730        740        750        760        770        780 
GMLGTTPEDI AQFLHQEERL DSTQVGEFLG DNDKFNKEVM YAYVDQHDFS GKDFVSALRL 
       790        800        810        820        830        840 
FLEGFRLPGE AQKIDRLMEK FAARYLECNQ GQTLFASADT AYVLAYSIIM LTTDLHSPQV 
       850        860        870        880        890        900 
KNKMTKEQYI KMNRGINDSK DLPEEYLSAI YNEIAGKKIS MKETKELTIP TKSTKQNVAS 
       910        920        930        940        950        960 
EKQRRLLYNL EMEQMAKTAK ALMEAVSHVQ APFTSATHLE HVRPMFKLAW TPFLAAFSVG 
       970        980        990       1000       1010       1020 
LQDCDDTEVA SLCLEGIRCA IRIACIFSIQ LERDAYVQAL ARFTLLTVSS GITEMKQKNI 
      1030       1040       1050       1060       1070       1080 
DTIKTLITVA HTDGNYLGNS WHEILKCISQ LELAQLIGTG VKPRYISGTV RGREGSLTGT 
      1090       1100       1110       1120       1130       1140 
KDQAPDEFVG LGLVGGNVDW KQIASIQESI GETSSQSVVV AVDRIFTGST RLDGNAIVDF 
      1150       1160       1170       1180       1190       1200 
VRWLCAVSMD ELLSTTHPRM FSLQKIVEIS YYNMGRIRLQ WSRIWEVIGD HFNKVGCNPN 
      1210       1220       1230       1240       1250       1260 
EDVAIFAVDS LRQLSMKFLE KGELANFRFQ KDFLRPFEHI MKRNRSPTIR DMVVRCIAQM 
      1270       1280       1290       1300       1310       1320 
VNSQAANIRS GWKNIFSVFH LAASDQDESI VELAFQTTGH IVTLVFEKHF PATIDSFQDA 
      1330       1340       1350       1360       1370       1380 
VKCLSEFACN AAFPDTSMEA IRLIRHCAKY VSDRPQAFKE YTSDDMSVAP EDRVWVRGWF 
      1390       1400       1410       1420       1430       1440 
PILFELSCII NRCKLDVRTR GLTVMFEIMK TYGHTYEKHW WQDLFRIVFR IFDNMKLPEQ 
      1450       1460       1470       1480       1490       1500 
QTEKAEWMTT TCNHALYAIC DVFTQYLEVL SDVLLDDIFA QLYWCVQQDN EQLARSGTNC 
      1510       1520       1530       1540       1550       1560 
LENVVILNGE KFTLEIWDKT CNCTLDIFKT TIPHALLTWR PTSGEAEPPS PSAVSEKPLD 
      1570       1580       1590       1600       1610       1620 
AISQKSVDIH DSIQPRSSDN RQQAPLVSVS TVSEEVSKVK STAKFPEQKL FAALLIKCVV 
      1630       1640       1650       1660       1670       1680 
QLELIQTIDN IVFFPATSKK EDAENLAAAQ RDAVDFDVRV DTQDQGMYRF LTSQQLFKLL 
      1690       1700       1710       1720       1730       1740 
DCLLESHRFA KAFNSNNEQR TALWKAGFKG KSKPNLLKQE TSSLACGLRI LFRMYMDESR 
      1750       1760       1770       1780       1790       1800 
VSAWEEVQQR LLNVCREALS YFLTLTSESH REAWTNLLLL FLTKVLKISD SRFKAHASFY 
      1810       1820       1830       1840    
YPLLCEIMQF DLIPELRAVL RRFFLRIGIV FQISQPPEQE LGINRQ

Isoforms



Sequence View



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Protein Neighborhood

Domains & Features

1 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    G3X9K3-1-unknown MYEGKK... 1 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...GINRQ 1846 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)