O00142: Thymidine kinase 2, mitochondrial

General Information

Protein names	- Thymidine kinase 2, mitochondrial - 2.7.1.21 - Mt-TK
Gene names	TK2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O00142

3 N-termini

3 C-termini

0 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform Short of Thymidine kinase 2, mitochondrial - Isoform 3 of Thymidine kinase 2, mitochondrial - Isoform 4 of Thymidine kinase 2, mitochondrial - Isoform 5 of Thymidine kinase 2, mitochondrial - Isoform 2 of Thymidine kinase 2, mitochondrial - Isoform 6 of Thymidine kinase 2, mitochondrial

Sequence View

        10         20         30         40         50         60
MLLWPLRGWA ARALRCFGPG SRGSPASGPG PRRVQRRAWP PDKEQEKEKK SVICVEGNIA
        70         80         90        100        110        120
SGKTTCLEFF SNATDVEVLT EPVSKWRNVR GHNPLGLMYH DASRWGLTLQ TYVQLTMLDR
       130        140        150        160        170        180
HTRPQVSSVR LMERSIHSAR YIFVENLYRS GKMPEVDYVV LSEWFDWILR NMDVSVDLIV
       190        200        210        220        230        240
YLRTNPETCY QRLKKRCREE EKVIPLEYLE AIHHLHEEWL IKGSLFPMAA PVLVIEADHH
       250        260
MERMLELFEQ NRDRILTPEN RKHCP         10         20         30         40         50         60
MLLWPLRGWA ARALRCFGPG SRGSPASGPG PRRVQRRAWP PDKEQEKEKK SVICVEGNIA
        70         80         90        100        110        120
SGKTTCLEFF SNATDVEVLT EPVSKWRNVR GHNPLGLMYH DASRWGLTLQ TYVQLTMLDR
       130        140        150        160        170        180
HTRPQVSSVR LMERSIHSAR YIFVENLYRS GKMPEVDYVV LSEWFDWILR NMDVSVDLIV
       190        200        210        220        230        240
YLRTNPETCY QRLKKRCREE EKVIPLEYLE AIHHLHEEWL IKGSLFPMAA PVLVIEADHH
       250        260
MERMLELFEQ NRDRILTPEN RKHCP         10         20         30         40         50         60
MLLWPLRGWA ARALRCFGPG SRGSPASGPG PRRVQRRAWP PDKEQEKEKK SVICVEGNIA
        70         80         90        100        110        120
SGKTTCLEFF SNATDVEVLT EPVSKWRNVR GHNPLGLMYH DASRWGLTLQ TYVQLTMLDR
       130        140        150        160        170        180
HTRPQVSSVR LMERSIHSAR YIFVENLYRS GKMPEVDYVV LSEWFDWILR NMDVSVDLIV
       190        200        210        220        230        240
YLRTNPETCY QRLKKRCREE EKVIPLEYLE AIHHLHEEWL IKGSLFPMAA PVLVIEADHH
       250        260
MERMLELFEQ NRDRILTPEN RKHCP         10         20         30         40         50         60
MLLWPLRGWA ARALRCFGPG SRGSPASGPG PRRVQRRAWP PDKEQEKEKK SVICVEGNIA
        70         80         90        100        110        120
SGKTTCLEFF SNATDVEVLT EPVSKWRNVR GHNPLGLMYH DASRWGLTLQ TYVQLTMLDR
       130        140        150        160        170        180
HTRPQVSSVR LMERSIHSAR YIFVENLYRS GKMPEVDYVV LSEWFDWILR NMDVSVDLIV
       190        200        210        220        230        240
YLRTNPETCY QRLKKRCREE EKVIPLEYLE AIHHLHEEWL IKGSLFPMAA PVLVIEADHH
       250        260
MERMLELFEQ NRDRILTPEN RKHCP         10         20         30         40         50         60
MLLWPLRGWA ARALRCFGPG SRGSPASGPG PRRVQRRAWP PDKEQEKEKK SVICVEGNIA
        70         80         90        100        110        120
SGKTTCLEFF SNATDVEVLT EPVSKWRNVR GHNPLGLMYH DASRWGLTLQ TYVQLTMLDR
       130        140        150        160        170        180
HTRPQVSSVR LMERSIHSAR YIFVENLYRS GKMPEVDYVV LSEWFDWILR NMDVSVDLIV
       190        200        210        220        230        240
YLRTNPETCY QRLKKRCREE EKVIPLEYLE AIHHLHEEWL IKGSLFPMAA PVLVIEADHH
       250        260
MERMLELFEQ NRDRILTPEN RKHCP         10         20         30         40         50         60
MLLWPLRGWA ARALRCFGPG SRGSPASGPG PRRVQRRAWP PDKEQEKEKK SVICVEGNIA
        70         80         90        100        110        120
SGKTTCLEFF SNATDVEVLT EPVSKWRNVR GHNPLGLMYH DASRWGLTLQ TYVQLTMLDR
       130        140        150        160        170        180
HTRPQVSSVR LMERSIHSAR YIFVENLYRS GKMPEVDYVV LSEWFDWILR NMDVSVDLIV
       190        200        210        220        230        240
YLRTNPETCY QRLKKRCREE EKVIPLEYLE AIHHLHEEWL IKGSLFPMAA PVLVIEADHH
       250        260
MERMLELFEQ NRDRILTPEN RKHCP

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

3 N-termini - 3 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
O00142-1-unknown	MLLWPL...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt79022
O00142-1-unknown	MLLWPL...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt79023
O00142-34-unknown	VQRRAW...	34	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
O00142-34-unknown	VQRRAW...	34	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt115145
O00142-98-unknown	MYHDAS...	98	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt79024
O00142-98-unknown	MYHDAS...	98	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000433770
O00142-98-unknown	MYHDAS...	98	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000434594
O00142-98-unknown	MYHDAS...	98	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000463560
O00142-98-unknown	MYHDAS...	98	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000462341
O00142-98-unknown	MYHDAS...	98	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000463326
O00142-98-unknown	MYHDAS...	98	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt105704
O00142-98-unknown	MYHDAS...	98	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt105703
O00142-98-unknown	MYHDAS...	98	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt105702

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...YLRTNP	185	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000463326
...YLRTNP	185	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt155467
...YLRTNP	185	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt155470
...YLRTNP	185	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt155469
...YLRTNP	185	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt155468
...GSLFPM	227	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000462341
...RKHCP	265	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...RKHCP	265	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt74642
...RKHCP	265	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt74639
...RKHCP	265	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt74640
...RKHCP	265	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt74641

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)