O00254: Proteinase-activated receptor 3

General Information

Protein names	- Proteinase-activated receptor 3 - PAR-3 - Coagulation factor II receptor-like 2 - Thrombin receptor-like 2
Gene names	F2RL2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O00254

3 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MKALIFAAAG LLLLLPTFCQ SGMENDTNNL AKPTLPIKTF RGAPPNSFEE FPFSALEGWT
        70         80         90        100        110        120
GATITVKIKC PEESASHLHV KNATMGYLTS SLSTKLIPAI YLLVFVVGVP ANAVTLWMLF
       130        140        150        160        170        180
FRTRSICTTV FYTNLAIADF LFCVTLPFKI AYHLNGNNWV FGEVLCRATT VIFYGNMYCS
       190        200        210        220        230        240
ILLLACISIN RYLAIVHPFT YRGLPKHTYA LVTCGLVWAT VFLYMLPFFI LKQEYYLVQP
       250        260        270        280        290        300
DITTCHDVHN TCESSSPFQL YYFISLAFFG FLIPFVLIIY CYAAIIRTLN AYDHRWLWYV
       310        320        330        340        350        360
KASLLILVIF TICFAPSNII LIIHHANYYY NNTDGLYFIY LIALCLGSLN SCLDPFLYFL
       370
MSKTRNHSTA YLTK

Isoforms

- Isoform 2 of Proteinase-activated receptor 3

Sequence View

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Protein Neighborhood

Domains & Features

3 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
O00254-22-unknown	GMENDT...	22	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
O00254-23-unknown	MENDTN...	23	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt84285
O00254-39-unknown	TFRGAP...	39	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
O00254-39-unknown	TFRGAP...	39	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31710
O00254-39-unknown	TFRGAP...	39	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt115376
O00254-39-unknown	TFRGAP...	39	inferred from similarity	unknown	UniProtKB	inferred from uniprot (by similarity)

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...TLPIKT	38	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31710
...AYLTK	374	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...AYLTK	374	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt79903

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
THRB_HUMAN	38	PIKT.\|.TFRG	inferred from experiment	unknown	MEROPS	Foster DC	Xu WF et al.:Cloning and characterization of... (S01.217)	9618465,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)