O00255: Menin

General Information

Protein names	- Menin
Gene names	MEN1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O00255

2 N-termini

1 C-termini

0 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Menin - Isoform 3 of Menin

Sequence View

        10         20         30         40         50         60
MGLKAAQKTL FPLRSIDDVV RLFAAELGRE EPDLVLLSLV LGFVEHFLAV NRVIPTNVPE
        70         80         90        100        110        120
LTFQPSPAPD PPGGLTYFPV ADLSIIAALY ARFTAQIRGA VDLSLYPREG GVSSRELVKK
       130        140        150        160        170        180
VSDVIWNSLS RSYFKDRAHI QSLFSFITGW SPVGTKLDSS GVAFAVVGAC QALGLRDVHL
       190        200        210        220        230        240
ALSEDHAWVV FGPNGEQTAE VTWHGKGNED RRGQTVNAGV AERSWLYLKG SYMRCDRKME
       250        260        270        280        290        300
VAFMVCAINP SIDLHTDSLE LLQLQQKLLW LLYDLGHLER YPMALGNLAD LEELEPTPGR
       310        320        330        340        350        360
PDPLTLYHKG IASAKTYYRD EHIYPYMYLA GYHCRNRNVR EALQAWADTA TVIQDYNYCR
       370        380        390        400        410        420
EDEEIYKEFF EVANDVIPNL LKEAASLLEA GEERPGEQSQ GTQSQGSALQ DPECFAHLLR
       430        440        450        460        470        480
FYDGICKWEE GSPTPVLHVG WATFLVQSLG RFEGQVRQKV RIVSREAEAA EAEEPWGEEA
       490        500        510        520        530        540
REGRRRGPRR ESKPEEPPPP KKPALDKGLG TGQGAVSGPP RKPPGTVAGT ARGPEGGSTA
       550        560        570        580        590        600
QVPAPTASPP PEGPVLTFQS EKMKGMKELL VATKINSSAI KLQLTAQSQV QMKKQKVSTP
       610
SDYTLSFLKR QRKGL         10         20         30         40         50         60
MGLKAAQKTL FPLRSIDDVV RLFAAELGRE EPDLVLLSLV LGFVEHFLAV NRVIPTNVPE
        70         80         90        100        110        120
LTFQPSPAPD PPGGLTYFPV ADLSIIAALY ARFTAQIRGA VDLSLYPREG GVSSRELVKK
       130        140        150        160        170        180
VSDVIWNSLS RSYFKDRAHI QSLFSFITGW SPVGTKLDSS GVAFAVVGAC QALGLRDVHL
       190        200        210        220        230        240
ALSEDHAWVV FGPNGEQTAE VTWHGKGNED RRGQTVNAGV AERSWLYLKG SYMRCDRKME
       250        260        270        280        290        300
VAFMVCAINP SIDLHTDSLE LLQLQQKLLW LLYDLGHLER YPMALGNLAD LEELEPTPGR
       310        320        330        340        350        360
PDPLTLYHKG IASAKTYYRD EHIYPYMYLA GYHCRNRNVR EALQAWADTA TVIQDYNYCR
       370        380        390        400        410        420
EDEEIYKEFF EVANDVIPNL LKEAASLLEA GEERPGEQSQ GTQSQGSALQ DPECFAHLLR
       430        440        450        460        470        480
FYDGICKWEE GSPTPVLHVG WATFLVQSLG RFEGQVRQKV RIVSREAEAA EAEEPWGEEA
       490        500        510        520        530        540
REGRRRGPRR ESKPEEPPPP KKPALDKGLG TGQGAVSGPP RKPPGTVAGT ARGPEGGSTA
       550        560        570        580        590        600
QVPAPTASPP PEGPVLTFQS EKMKGMKELL VATKINSSAI KLQLTAQSQV QMKKQKVSTP
       610
SDYTLSFLKR QRKGL

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

2 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
O00255-1-unknown	MGLKAA...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O00255-1-unknown	MGLKAA...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt80887
O00255-1-unknown	MGLKAA...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt80888
O00255-2-unknown	GLKAAQ...	2		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
O00255-2-unknown	GLKAAQ...	2		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
O00255-2-unknown	GLKAAQ...	2	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt162727
O00255-2-unknown	GLKAAQ...	2	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt162728

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...QRKGL	615	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...QRKGL	615	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt76506
...QRKGL	615	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt76505

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)