O00429: Dynamin-1-like protein

General Information

Protein names	- Dynamin-1-like protein - 3.6.5.5 - Dnm1p/Vps1p-like protein - DVLP - Dynamin family member proline-rich carboxyl-terminal domain less - Dymple - Dynamin-like protein - Dynamin-like protein 4 - Dynamin-like protein IV - HdynIV - Dynamin-related protein 1
Gene names	DNM1L
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O00429

7 N-termini

4 C-termini

0 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 4 of Dynamin-1-like protein - Isoform 2 of Dynamin-1-like protein - Isoform 3 of Dynamin-1-like protein - Isoform 5 of Dynamin-1-like protein - Isoform 6 of Dynamin-1-like protein - Isoform 7 of Dynamin-1-like protein - Isoform 8 of Dynamin-1-like protein

Sequence View

        10         20         30         40         50         60
MEALIPVINK LQDVFNTVGA DIIQLPQIVV VGTQSSGKSS VLESLVGRDL LPRGTGIVTR
        70         80         90        100        110        120
RPLILQLVHV SQEDKRKTTG EENGVEAEEW GKFLHTKNKL YTDFDEIRQE IENETERISG
       130        140        150        160        170        180
NNKGVSPEPI HLKIFSPNVV NLTLVDLPGM TKVPVGDQPK DIELQIRELI LRFISNPNSI
       190        200        210        220        230        240
ILAVTAANTD MATSEALKIS REVDPDGRRT LAVITKLDLM DAGTDAMDVL MGRVIPVKLG
       250        260        270        280        290        300
IIGVVNRSQL DINNKKSVTD SIRDEYAFLQ KKYPSLANRN GTKYLARTLN RLLMHHIRDC
       310        320        330        340        350        360
LPELKTRINV LAAQYQSLLN SYGEPVDDKS ATLLQLITKF ATEYCNTIEG TAKYIETSEL
       370        380        390        400        410        420
CGGARICYIF HETFGRTLES VDPLGGLNTI DILTAIRNAT GPRPALFVPE VSFELLVKRQ
       430        440        450        460        470        480
IKRLEEPSLR CVELVHEEMQ RIIQHCSNYS TQELLRFPKL HDAIVEVVTC LLRKRLPVTN
       490        500        510        520        530        540
EMVHNLVAIE LAYINTKHPD FADACGLMNN NIEEQRRNRL ARELPSAVSR DKSSKVPSAL
       550        560        570        580        590        600
APASQEPSPA ASAEADGKLI QDSRRETKNV ASGGGGVGDG VQEPTTGNWR GMLKTSKAEE
       610        620        630        640        650        660
LLAEEKSKPI PIMPASPQKG HAVNLLDVPV PVARKLSARE QRDCEVIERL IKSYFLIVRK
       670        680        690        700        710        720
NIQDSVPKAV MHFLVNHVKD TLQSELVGQL YKSSLLDDLL TESEDMAQRR KEAADMLKAL
       730
QGASQIIAEI RETHLW         10         20         30         40         50         60
MEALIPVINK LQDVFNTVGA DIIQLPQIVV VGTQSSGKSS VLESLVGRDL LPRGTGIVTR
        70         80         90        100        110        120
RPLILQLVHV SQEDKRKTTG EENGVEAEEW GKFLHTKNKL YTDFDEIRQE IENETERISG
       130        140        150        160        170        180
NNKGVSPEPI HLKIFSPNVV NLTLVDLPGM TKVPVGDQPK DIELQIRELI LRFISNPNSI
       190        200        210        220        230        240
ILAVTAANTD MATSEALKIS REVDPDGRRT LAVITKLDLM DAGTDAMDVL MGRVIPVKLG
       250        260        270        280        290        300
IIGVVNRSQL DINNKKSVTD SIRDEYAFLQ KKYPSLANRN GTKYLARTLN RLLMHHIRDC
       310        320        330        340        350        360
LPELKTRINV LAAQYQSLLN SYGEPVDDKS ATLLQLITKF ATEYCNTIEG TAKYIETSEL
       370        380        390        400        410        420
CGGARICYIF HETFGRTLES VDPLGGLNTI DILTAIRNAT GPRPALFVPE VSFELLVKRQ
       430        440        450        460        470        480
IKRLEEPSLR CVELVHEEMQ RIIQHCSNYS TQELLRFPKL HDAIVEVVTC LLRKRLPVTN
       490        500        510        520        530        540
EMVHNLVAIE LAYINTKHPD FADACGLMNN NIEEQRRNRL ARELPSAVSR DKSSKVPSAL
       550        560        570        580        590        600
APASQEPSPA ASAEADGKLI QDSRRETKNV ASGGGGVGDG VQEPTTGNWR GMLKTSKAEE
       610        620        630        640        650        660
LLAEEKSKPI PIMPASPQKG HAVNLLDVPV PVARKLSARE QRDCEVIERL IKSYFLIVRK
       670        680        690        700        710        720
NIQDSVPKAV MHFLVNHVKD TLQSELVGQL YKSSLLDDLL TESEDMAQRR KEAADMLKAL
       730
QGASQIIAEI RETHLW         10         20         30         40         50         60
MEALIPVINK LQDVFNTVGA DIIQLPQIVV VGTQSSGKSS VLESLVGRDL LPRGTGIVTR
        70         80         90        100        110        120
RPLILQLVHV SQEDKRKTTG EENGVEAEEW GKFLHTKNKL YTDFDEIRQE IENETERISG
       130        140        150        160        170        180
NNKGVSPEPI HLKIFSPNVV NLTLVDLPGM TKVPVGDQPK DIELQIRELI LRFISNPNSI
       190        200        210        220        230        240
ILAVTAANTD MATSEALKIS REVDPDGRRT LAVITKLDLM DAGTDAMDVL MGRVIPVKLG
       250        260        270        280        290        300
IIGVVNRSQL DINNKKSVTD SIRDEYAFLQ KKYPSLANRN GTKYLARTLN RLLMHHIRDC
       310        320        330        340        350        360
LPELKTRINV LAAQYQSLLN SYGEPVDDKS ATLLQLITKF ATEYCNTIEG TAKYIETSEL
       370        380        390        400        410        420
CGGARICYIF HETFGRTLES VDPLGGLNTI DILTAIRNAT GPRPALFVPE VSFELLVKRQ
       430        440        450        460        470        480
IKRLEEPSLR CVELVHEEMQ RIIQHCSNYS TQELLRFPKL HDAIVEVVTC LLRKRLPVTN
       490        500        510        520        530        540
EMVHNLVAIE LAYINTKHPD FADACGLMNN NIEEQRRNRL ARELPSAVSR DKSSKVPSAL
       550        560        570        580        590        600
APASQEPSPA ASAEADGKLI QDSRRETKNV ASGGGGVGDG VQEPTTGNWR GMLKTSKAEE
       610        620        630        640        650        660
LLAEEKSKPI PIMPASPQKG HAVNLLDVPV PVARKLSARE QRDCEVIERL IKSYFLIVRK
       670        680        690        700        710        720
NIQDSVPKAV MHFLVNHVKD TLQSELVGQL YKSSLLDDLL TESEDMAQRR KEAADMLKAL
       730
QGASQIIAEI RETHLW         10         20         30         40         50         60
MEALIPVINK LQDVFNTVGA DIIQLPQIVV VGTQSSGKSS VLESLVGRDL LPRGTGIVTR
        70         80         90        100        110        120
RPLILQLVHV SQEDKRKTTG EENGVEAEEW GKFLHTKNKL YTDFDEIRQE IENETERISG
       130        140        150        160        170        180
NNKGVSPEPI HLKIFSPNVV NLTLVDLPGM TKVPVGDQPK DIELQIRELI LRFISNPNSI
       190        200        210        220        230        240
ILAVTAANTD MATSEALKIS REVDPDGRRT LAVITKLDLM DAGTDAMDVL MGRVIPVKLG
       250        260        270        280        290        300
IIGVVNRSQL DINNKKSVTD SIRDEYAFLQ KKYPSLANRN GTKYLARTLN RLLMHHIRDC
       310        320        330        340        350        360
LPELKTRINV LAAQYQSLLN SYGEPVDDKS ATLLQLITKF ATEYCNTIEG TAKYIETSEL
       370        380        390        400        410        420
CGGARICYIF HETFGRTLES VDPLGGLNTI DILTAIRNAT GPRPALFVPE VSFELLVKRQ
       430        440        450        460        470        480
IKRLEEPSLR CVELVHEEMQ RIIQHCSNYS TQELLRFPKL HDAIVEVVTC LLRKRLPVTN
       490        500        510        520        530        540
EMVHNLVAIE LAYINTKHPD FADACGLMNN NIEEQRRNRL ARELPSAVSR DKSSKVPSAL
       550        560        570        580        590        600
APASQEPSPA ASAEADGKLI QDSRRETKNV ASGGGGVGDG VQEPTTGNWR GMLKTSKAEE
       610        620        630        640        650        660
LLAEEKSKPI PIMPASPQKG HAVNLLDVPV PVARKLSARE QRDCEVIERL IKSYFLIVRK
       670        680        690        700        710        720
NIQDSVPKAV MHFLVNHVKD TLQSELVGQL YKSSLLDDLL TESEDMAQRR KEAADMLKAL
       730
QGASQIIAEI RETHLW         10         20         30         40         50         60
MEALIPVINK LQDVFNTVGA DIIQLPQIVV VGTQSSGKSS VLESLVGRDL LPRGTGIVTR
        70         80         90        100        110        120
RPLILQLVHV SQEDKRKTTG EENGVEAEEW GKFLHTKNKL YTDFDEIRQE IENETERISG
       130        140        150        160        170        180
NNKGVSPEPI HLKIFSPNVV NLTLVDLPGM TKVPVGDQPK DIELQIRELI LRFISNPNSI
       190        200        210        220        230        240
ILAVTAANTD MATSEALKIS REVDPDGRRT LAVITKLDLM DAGTDAMDVL MGRVIPVKLG
       250        260        270        280        290        300
IIGVVNRSQL DINNKKSVTD SIRDEYAFLQ KKYPSLANRN GTKYLARTLN RLLMHHIRDC
       310        320        330        340        350        360
LPELKTRINV LAAQYQSLLN SYGEPVDDKS ATLLQLITKF ATEYCNTIEG TAKYIETSEL
       370        380        390        400        410        420
CGGARICYIF HETFGRTLES VDPLGGLNTI DILTAIRNAT GPRPALFVPE VSFELLVKRQ
       430        440        450        460        470        480
IKRLEEPSLR CVELVHEEMQ RIIQHCSNYS TQELLRFPKL HDAIVEVVTC LLRKRLPVTN
       490        500        510        520        530        540
EMVHNLVAIE LAYINTKHPD FADACGLMNN NIEEQRRNRL ARELPSAVSR DKSSKVPSAL
       550        560        570        580        590        600
APASQEPSPA ASAEADGKLI QDSRRETKNV ASGGGGVGDG VQEPTTGNWR GMLKTSKAEE
       610        620        630        640        650        660
LLAEEKSKPI PIMPASPQKG HAVNLLDVPV PVARKLSARE QRDCEVIERL IKSYFLIVRK
       670        680        690        700        710        720
NIQDSVPKAV MHFLVNHVKD TLQSELVGQL YKSSLLDDLL TESEDMAQRR KEAADMLKAL
       730
QGASQIIAEI RETHLW         10         20         30         40         50         60
MEALIPVINK LQDVFNTVGA DIIQLPQIVV VGTQSSGKSS VLESLVGRDL LPRGTGIVTR
        70         80         90        100        110        120
RPLILQLVHV SQEDKRKTTG EENGVEAEEW GKFLHTKNKL YTDFDEIRQE IENETERISG
       130        140        150        160        170        180
NNKGVSPEPI HLKIFSPNVV NLTLVDLPGM TKVPVGDQPK DIELQIRELI LRFISNPNSI
       190        200        210        220        230        240
ILAVTAANTD MATSEALKIS REVDPDGRRT LAVITKLDLM DAGTDAMDVL MGRVIPVKLG
       250        260        270        280        290        300
IIGVVNRSQL DINNKKSVTD SIRDEYAFLQ KKYPSLANRN GTKYLARTLN RLLMHHIRDC
       310        320        330        340        350        360
LPELKTRINV LAAQYQSLLN SYGEPVDDKS ATLLQLITKF ATEYCNTIEG TAKYIETSEL
       370        380        390        400        410        420
CGGARICYIF HETFGRTLES VDPLGGLNTI DILTAIRNAT GPRPALFVPE VSFELLVKRQ
       430        440        450        460        470        480
IKRLEEPSLR CVELVHEEMQ RIIQHCSNYS TQELLRFPKL HDAIVEVVTC LLRKRLPVTN
       490        500        510        520        530        540
EMVHNLVAIE LAYINTKHPD FADACGLMNN NIEEQRRNRL ARELPSAVSR DKSSKVPSAL
       550        560        570        580        590        600
APASQEPSPA ASAEADGKLI QDSRRETKNV ASGGGGVGDG VQEPTTGNWR GMLKTSKAEE
       610        620        630        640        650        660
LLAEEKSKPI PIMPASPQKG HAVNLLDVPV PVARKLSARE QRDCEVIERL IKSYFLIVRK
       670        680        690        700        710        720
NIQDSVPKAV MHFLVNHVKD TLQSELVGQL YKSSLLDDLL TESEDMAQRR KEAADMLKAL
       730
QGASQIIAEI RETHLW         10         20         30         40         50         60
MEALIPVINK LQDVFNTVGA DIIQLPQIVV VGTQSSGKSS VLESLVGRDL LPRGTGIVTR
        70         80         90        100        110        120
RPLILQLVHV SQEDKRKTTG EENGVEAEEW GKFLHTKNKL YTDFDEIRQE IENETERISG
       130        140        150        160        170        180
NNKGVSPEPI HLKIFSPNVV NLTLVDLPGM TKVPVGDQPK DIELQIRELI LRFISNPNSI
       190        200        210        220        230        240
ILAVTAANTD MATSEALKIS REVDPDGRRT LAVITKLDLM DAGTDAMDVL MGRVIPVKLG
       250        260        270        280        290        300
IIGVVNRSQL DINNKKSVTD SIRDEYAFLQ KKYPSLANRN GTKYLARTLN RLLMHHIRDC
       310        320        330        340        350        360
LPELKTRINV LAAQYQSLLN SYGEPVDDKS ATLLQLITKF ATEYCNTIEG TAKYIETSEL
       370        380        390        400        410        420
CGGARICYIF HETFGRTLES VDPLGGLNTI DILTAIRNAT GPRPALFVPE VSFELLVKRQ
       430        440        450        460        470        480
IKRLEEPSLR CVELVHEEMQ RIIQHCSNYS TQELLRFPKL HDAIVEVVTC LLRKRLPVTN
       490        500        510        520        530        540
EMVHNLVAIE LAYINTKHPD FADACGLMNN NIEEQRRNRL ARELPSAVSR DKSSKVPSAL
       550        560        570        580        590        600
APASQEPSPA ASAEADGKLI QDSRRETKNV ASGGGGVGDG VQEPTTGNWR GMLKTSKAEE
       610        620        630        640        650        660
LLAEEKSKPI PIMPASPQKG HAVNLLDVPV PVARKLSARE QRDCEVIERL IKSYFLIVRK
       670        680        690        700        710        720
NIQDSVPKAV MHFLVNHVKD TLQSELVGQL YKSSLLDDLL TESEDMAQRR KEAADMLKAL
       730
QGASQIIAEI RETHLW

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

7 N-termini - 4 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
O00429-1-unknown	MEALIP...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt73063
O00429-1-unknown	MEALIP...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt73064
O00429-1-unknown	MEALIP...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt73065
O00429-1-unknown	MEALIP...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt73066
O00429-1-unknown	MEALIP...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt73067
O00429-1-unknown	MEALIP...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt73069
O00429-1-Acetylation	MEALIP...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O00429-1-Acetylation	MEALIP...	1	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
O00429-1-Acetylation	MEALIP...	1	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt106908
O00429-1-Acetylation	MEALIP...	1	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt106909
O00429-1-Acetylation	MEALIP...	1	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt106910
O00429-1-Acetylation	MEALIP...	1	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt106911
O00429-1-Acetylation	MEALIP...	1	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt106912
O00429-1-Acetylation	MEALIP...	1	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt106913
O00429-504-unknown	ACGLMN...	504			unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
O00429-504-unknown	ACGLMN...	504		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt161461
O00429-504-unknown	ACGLMN...	504		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt161463
O00429-504-unknown	ACGLMN...	504		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt161464
O00429-504-unknown	ACGLMN...	504		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt161465
O00429-504-unknown	ACGLMN...	504		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt161466
O00429-504-unknown	ACGLMN...	504		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt161460
O00429-504-unknown	ACGLMN...	504		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt161462
O00429-580-	GVQEPT...	580			Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
O00429-580-	GVQEPT...	580			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
O00429-580-unknown	GVQEPT...	580		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt165932
O00429-580-unknown	GVQEPT...	580		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt165935
O00429-580-unknown	GVQEPT...	580		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt165934
O00429-580-unknown	GVQEPT...	580		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt165936
O00429-580-unknown	GVQEPT...	580		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt165937
O00429-580-unknown	GVQEPT...	580		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt165931
O00429-580-unknown	GVQEPT...	580		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt165933
O00429-595-	TSKAEE...	595			Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
O00429-595-unknown	TSKAEE...	595		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt165924
O00429-595-unknown	TSKAEE...	595		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt165927
O00429-595-unknown	TSKAEE...	595		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt165926
O00429-595-unknown	TSKAEE...	595		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt165928
O00429-595-unknown	TSKAEE...	595		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt165929
O00429-595-unknown	TSKAEE...	595		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt165923
O00429-595-unknown	TSKAEE...	595		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt165925
O00429-595-unknown	TSKAEE...	595		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...TAANTD	189	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000447845
...TAANTD	189	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt155511
...TAANTD	189	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt155512
...TAANTD	189	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt155513
...TAANTD	189	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt155514
...TAANTD	189	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt155509
...TAANTD	189	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt155510
...NTDMAT	192	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000447013
...NTDMAT	192	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt155537
...NTDMAT	192	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt155538
...NTDMAT	192	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt155539
...NTDMAT	192	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt155540
...NTDMAT	192	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt155535
...NTDMAT	192	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt155536
...ARTLNR	290	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000447788
...ETHLW	736	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...ETHLW	736	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt68686
...ETHLW	736	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt68683
...ETHLW	736	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt68682
...ETHLW	736	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt68684
...ETHLW	736	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt68681
...ETHLW	736	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt68687
...ETHLW	736	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt68685

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)