O00451: GDNF family receptor alpha-2
| Protein names | - GDNF family receptor alpha-2 - GDNF receptor alpha-2 - GDNFR-alpha-2 - GFR-alpha-2 - GDNF receptor beta - GDNFR-beta - Neurturin receptor alpha - NRTNR-alpha - NTNR-alpha - RET ligand 2 - TGF-beta-related neurotrophic factor receptor 2 |
|---|---|
| Gene names | GFRA2 |
| Organism | Homo sapiens |
| Protease Family | |
| Protease ID | |
| Chromosome location | |
| UniProt ID | O00451 |
2
N-termini
2
C-termini
0
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MILANVFCLF FFLDETLRSL ASPSSLQGPE LHGWRPPVDC VRANELCAAE SNCSSRYRTL
70 80 90 100 110 120
RQCLAGRDRN TMLANKECQA ALEVLQESPL YDCRCKRGMK KELQCLQIYW SIHLGLTEGE
130 140 150 160 170 180
EFYEASPYEP VTSRLSDIFR LASIFSGTGA DPVVSAKSNH CLDAAKACNL NDNCKKLRSS
190 200 210 220 230 240
YISICNREIS PTERCNRRKC HKALRQFFDR VPSEYTYRML FCSCQDQACA ERRRQTILPS
250 260 270 280 290 300
CSYEDKEKPN CLDLRGVCRT DHLCRSRLAD FHANCRASYQ TVTSCPADNY QACLGSYAGM
310 320 330 340 350 360
IGFDMTPNYV DSSPTGIVVS PWCSCRGSGN MEEECEKFLR DFTENPCLRN AIQAFGNGTD
370 380 390 400 410 420
VNVSPKGPSF QATQAPRVEK TPSLPDDLSD STSLGTSVIT TCTSVQEQGL KANNSKELSM
430 440 450 460
CFTELTTNII PGSNKVIKPN SGPSRARPSA ALTVLSVLML KLAL
Isoforms
- Isoform 2 of GDNF family receptor alpha-2 - Isoform 3 of GDNF family receptor alpha-2Sequence View
10 20 30 40 50 60
MILANVFCLF FFLDETLRSL ASPSSLQGPE LHGWRPPVDC VRANELCAAE SNCSSRYRTL
70 80 90 100 110 120
RQCLAGRDRN TMLANKECQA ALEVLQESPL YDCRCKRGMK KELQCLQIYW SIHLGLTEGE
130 140 150 160 170 180
EFYEASPYEP VTSRLSDIFR LASIFSGTGA DPVVSAKSNH CLDAAKACNL NDNCKKLRSS
190 200 210 220 230 240
YISICNREIS PTERCNRRKC HKALRQFFDR VPSEYTYRML FCSCQDQACA ERRRQTILPS
250 260 270 280 290 300
CSYEDKEKPN CLDLRGVCRT DHLCRSRLAD FHANCRASYQ TVTSCPADNY QACLGSYAGM
310 320 330 340 350 360
IGFDMTPNYV DSSPTGIVVS PWCSCRGSGN MEEECEKFLR DFTENPCLRN AIQAFGNGTD
370 380 390 400 410 420
VNVSPKGPSF QATQAPRVEK TPSLPDDLSD STSLGTSVIT TCTSVQEQGL KANNSKELSM
430 440 450 460
CFTELTTNII PGSNKVIKPN SGPSRARPSA ALTVLSVLML KLAL
10 20 30 40 50 60
MILANVFCLF FFLDETLRSL ASPSSLQGPE LHGWRPPVDC VRANELCAAE SNCSSRYRTL
70 80 90 100 110 120
RQCLAGRDRN TMLANKECQA ALEVLQESPL YDCRCKRGMK KELQCLQIYW SIHLGLTEGE
130 140 150 160 170 180
EFYEASPYEP VTSRLSDIFR LASIFSGTGA DPVVSAKSNH CLDAAKACNL NDNCKKLRSS
190 200 210 220 230 240
YISICNREIS PTERCNRRKC HKALRQFFDR VPSEYTYRML FCSCQDQACA ERRRQTILPS
250 260 270 280 290 300
CSYEDKEKPN CLDLRGVCRT DHLCRSRLAD FHANCRASYQ TVTSCPADNY QACLGSYAGM
310 320 330 340 350 360
IGFDMTPNYV DSSPTGIVVS PWCSCRGSGN MEEECEKFLR DFTENPCLRN AIQAFGNGTD
370 380 390 400 410 420
VNVSPKGPSF QATQAPRVEK TPSLPDDLSD STSLGTSVIT TCTSVQEQGL KANNSKELSM
430 440 450 460
CFTELTTNII PGSNKVIKPN SGPSRARPSA ALTVLSVLML KLAL
Protein Neighborhood
Domains & Features
2 N-termini - 2 C-termini - 0 Cleavages - 0 Substrates
N-termini
| Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
|---|---|---|---|---|---|---|---|---|---|
| O00451-22-unknown | SPSSLQ... | 22 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
| O00451-143-unknown | SIFSGT... | 143 | unknown | Wildes D. et al: Sampling the N-terminal proteome of human blood | 20173099 | ||||
| O00451-143-unknown | SIFSGT... | 143 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt180414 |
C-termini
| Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|---|---|---|---|---|---|---|---|
| ...NSGPSR | 444 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
| ...NSGPSR | 444 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt92784 | |||
| ...NSGPSR | 444 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt92783 | |||
| ...LKLAL | 464 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt71520 | |||
| ...LKLAL | 464 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt71521 |
Cleavages
| Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|
Substrates
| Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|