O00748: Cocaine esterase

General Information

Protein names	- Cocaine esterase - 3.1.1.84 - Carboxylesterase 2 - CE-2 - hCE-2 - 3.1.1.1 - Methylumbelliferyl-acetate deacetylase 2 - 3.1.1.56
Gene names	CES2
Organism	Homo sapiens
Protease Family
Protease ID	S09.984
Chromosome location
UniProt ID	O00748

3 N-termini

3 C-termini

0 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Cocaine esterase - Isoform 3 of Cocaine esterase - Isoform 4 of Cocaine esterase

Sequence View

        10         20         30         40         50         60
MRLHRLRARL SAVACGLLLL LVRGQGQDSA SPIRTTHTGQ VLGSLVHVKG ANAGVQTFLG
        70         80         90        100        110        120
IPFAKPPLGP LRFAPPEPPE SWSGVRDGTT HPAMCLQDLT AVESEFLSQF NMTFPSDSMS
       130        140        150        160        170        180
EDCLYLSIYT PAHSHEGSNL PVMVWIHGGA LVFGMASLYD GSMLAALENV VVVIIQYRLG
       190        200        210        220        230        240
VLGFFSTGDK HATGNWGYLD QVAALRWVQQ NIAHFGGNPD RVTIFGESAG GTSVSSLVVS
       250        260        270        280        290        300
PISQGLFHGA IMESGVALLP GLIASSADVI STVVANLSAC DQVDSEALVG CLRGKSKEEI
       310        320        330        340        350        360
LAINKPFKMI PGVVDGVFLP RHPQELLASA DFQPVPSIVG VNNNEFGWLI PKVMRIYDTQ
       370        380        390        400        410        420
KEMDREASQA ALQKMLTLLM LPPTFGDLLR EEYIGDNGDP QTLQAQFQEM MADSMFVIPA
       430        440        450        460        470        480
LQVAHFQCSR APVYFYEFQH QPSWLKNIRP PHMKADHGDE LPFVFRSFFG GNYIKFTEEE
       490        500        510        520        530        540
EQLSRKMMKY WANFARNGNP NGEGLPHWPL FDQEEQYLQL NLQPAVGRAL KAHRLQFWKK
       550
ALPQKIQELE EPEERHTEL         10         20         30         40         50         60
MRLHRLRARL SAVACGLLLL LVRGQGQDSA SPIRTTHTGQ VLGSLVHVKG ANAGVQTFLG
        70         80         90        100        110        120
IPFAKPPLGP LRFAPPEPPE SWSGVRDGTT HPAMCLQDLT AVESEFLSQF NMTFPSDSMS
       130        140        150        160        170        180
EDCLYLSIYT PAHSHEGSNL PVMVWIHGGA LVFGMASLYD GSMLAALENV VVVIIQYRLG
       190        200        210        220        230        240
VLGFFSTGDK HATGNWGYLD QVAALRWVQQ NIAHFGGNPD RVTIFGESAG GTSVSSLVVS
       250        260        270        280        290        300
PISQGLFHGA IMESGVALLP GLIASSADVI STVVANLSAC DQVDSEALVG CLRGKSKEEI
       310        320        330        340        350        360
LAINKPFKMI PGVVDGVFLP RHPQELLASA DFQPVPSIVG VNNNEFGWLI PKVMRIYDTQ
       370        380        390        400        410        420
KEMDREASQA ALQKMLTLLM LPPTFGDLLR EEYIGDNGDP QTLQAQFQEM MADSMFVIPA
       430        440        450        460        470        480
LQVAHFQCSR APVYFYEFQH QPSWLKNIRP PHMKADHGDE LPFVFRSFFG GNYIKFTEEE
       490        500        510        520        530        540
EQLSRKMMKY WANFARNGNP NGEGLPHWPL FDQEEQYLQL NLQPAVGRAL KAHRLQFWKK
       550
ALPQKIQELE EPEERHTEL         10         20         30         40         50         60
MRLHRLRARL SAVACGLLLL LVRGQGQDSA SPIRTTHTGQ VLGSLVHVKG ANAGVQTFLG
        70         80         90        100        110        120
IPFAKPPLGP LRFAPPEPPE SWSGVRDGTT HPAMCLQDLT AVESEFLSQF NMTFPSDSMS
       130        140        150        160        170        180
EDCLYLSIYT PAHSHEGSNL PVMVWIHGGA LVFGMASLYD GSMLAALENV VVVIIQYRLG
       190        200        210        220        230        240
VLGFFSTGDK HATGNWGYLD QVAALRWVQQ NIAHFGGNPD RVTIFGESAG GTSVSSLVVS
       250        260        270        280        290        300
PISQGLFHGA IMESGVALLP GLIASSADVI STVVANLSAC DQVDSEALVG CLRGKSKEEI
       310        320        330        340        350        360
LAINKPFKMI PGVVDGVFLP RHPQELLASA DFQPVPSIVG VNNNEFGWLI PKVMRIYDTQ
       370        380        390        400        410        420
KEMDREASQA ALQKMLTLLM LPPTFGDLLR EEYIGDNGDP QTLQAQFQEM MADSMFVIPA
       430        440        450        460        470        480
LQVAHFQCSR APVYFYEFQH QPSWLKNIRP PHMKADHGDE LPFVFRSFFG GNYIKFTEEE
       490        500        510        520        530        540
EQLSRKMMKY WANFARNGNP NGEGLPHWPL FDQEEQYLQL NLQPAVGRAL KAHRLQFWKK
       550
ALPQKIQELE EPEERHTEL

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

3 N-termini - 3 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
O00748-1-unknown	MRLHRL...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt74231
O00748-27-unknown	QDSASP...	27	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
O00748-27-unknown	QDSASP...	27	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt114321
O00748-94-unknown	MCLQDL...	94	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000463641
O00748-94-unknown	MCLQDL...	94	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt130375

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...HFGGNP	218	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000463641
...HFGGNP	218	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt109631
...FARNGN	498	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000464620
...FARNGN	498	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt109633
...RHTEL	559	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...RHTEL	559	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt69849

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)