O00750: Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta

General Information

Protein names	- Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta - PI3K-C2-beta - PtdIns-3-kinase C2 subunit beta - 2.7.1.154 - C2-PI3K - Phosphoinositide 3-kinase-C2-beta
Gene names	PIK3C2B
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O00750

3 N-termini

4 C-termini

0 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MSSTQGNGEH WKSLESVGIS RKELAMAEAL QMEYDALSRL RHDKEENRAK QNADPSLISW
        70         80         90        100        110        120
DEPGVDFYSK PAGRRTDLKL LRGLSGSDPT LNYNSLSPQE GPPNHSTSQG PQPGSDPWPK
       130        140        150        160        170        180
GSLSGDYLYI FDGSDGGVSS SPGPGDIEGS CKKLSPPPLP PRASIWDTPP LPPRKGSPSS
       190        200        210        220        230        240
SKISQPSDIN TFSLVEQLPG KLLEHRILEE EEVLGGGGQG RLLGSVDYDG INDAITRLNL
       250        260        270        280        290        300
KSTYDAEMLR DATRGWKEGR GPLDFSKDTS GKPVARSKTM PPQVPPRTYA SRYGNRKNAT
       310        320        330        340        350        360
PGKNRRISAA PVGSRPHTVA NGHELFEVSE ERDEEVAAFC HMLDILRSGS DIQDYFLTGY
       370        380        390        400        410        420
VWSAVTPSPE HLGDEVNLKV TVLCDRLQEA LTFTCNCSST VDLLIYQTLC YTHDDLRNVD
       430        440        450        460        470        480
VGDFVLKPCG LEEFLQNKHA LGSHEYIQYC RKFDIDIRLQ LMEQKVVRSD LARTVNDDQS
       490        500        510        520        530        540
PSTLNYLVHL QERPVKQTIS RQALSLLFDT YHNEVDAFLL ADGDFPLKAD RVVQSVKAIC
       550        560        570        580        590        600
NALAAVETPE ITSALNQLPP CPSRMQPKIQ KDPSVLAVRE NREKVVEALT AAILDLVELY
       610        620        630        640        650        660
CNTFNADFQT AVPGSRKHDL VQEACHFARS LAFTVYATHR IPIIWATSYE DFYLSCSLSH
       670        680        690        700        710        720
GGKELCSPLQ TRRAHFSKYL FHLIVWDQQI CFPVQVNRLP RETLLCATLY ALPIPPPGSS
       730        740        750        760        770        780
SEANKQRRVP EALGWVTTPL FNFRQVLTCG RKLLGLWPAT QENPSARWSA PNFHQPDSVI
       790        800        810        820        830        840
LQIDFPTSAF DIKFTSPPGD KFSPRYEFGS LREEDQRKLK DIMQKESLYW LTDADKKRLW
       850        860        870        880        890        900
EKRYYCHSEV SSLPLVLASA PSWEWACLPD IYVLLKQWTH MNHQDALGLL HATFPDQEVR
       910        920        930        940        950        960
RMAVQWIGSL SDAELLDYLP QLVQALKYEC YLDSPLVRFL LKRAVSDLRV THYFFWLLKD
       970        980        990       1000       1010       1020
GLKDSQFSIR YQYLLAALLC CCGKGLREEF NRQCWLVNAL AKLAQQVREA APSARQGILR
      1030       1040       1050       1060       1070       1080
TGLEEVKQFF ALNGSCRLPL SPSLLVKGIV PRDCSYFNSN AVPLKLSFQN VDPLGENIRV
      1090       1100       1110       1120       1130       1140
IFKCGDDLRQ DMLTLQMIRI MSKIWVQEGL DMRMVIFRCF STGRGRGMVE MIPNAETLRK
      1150       1160       1170       1180       1190       1200
IQVEHGVTGS FKDRPLADWL QKHNPGEDEY EKAVENFIYS CAGCCVATYV LGICDRHNDN
      1210       1220       1230       1240       1250       1260
IMLKTTGHMF HIDFGRFLGH AQMFGNIKRD RAPFVFTSDM AYVINGGDKP SSRFHDFVDL
      1270       1280       1290       1300       1310       1320
CCQAYNLIRK HTHLFLNLLG LMLSCGIPEL SDLEDLKYVY DALRPQDTEA NATTYFTRLI
      1330       1340       1350       1360       1370       1380
ESSLGSVATK LNFFIHNLAQ MKFTGSDDRL TLSFASRTHT LKSSGRISDV FLCRHEKIFH
      1390       1400       1410       1420       1430       1440
PNKGYIYVVK VMRENTHEAT YIQRTFEEFQ ELHNKLRLLF PSSHLPSFPS RFVIGRSRGE
      1450       1460       1470       1480       1490       1500
AVAERRREEL NGYIWHLIHA PPEVAECDLV YTFFHPLPRD EKAMGTSPAP KSSDGTWARP
      1510       1520       1530       1540       1550       1560
VGKVGGEVKL SISYKNNKLF IMVMHIRGLQ LLQDGNDPDP YVKIYLLPDP QKTTKRKTKV
      1570       1580       1590       1600       1610       1620
ARKTCNPTYN EMLVYDGIPK GDLQQRELQL SVLSEQGFWE NVLLGEVNIR LRELDLAQEK
      1630
TGWFALGSRS HGTL

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

3 N-termini - 4 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
O00750-1-unknown	MSSTQG...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O00750-193-unknown	SLVEQL...	193		unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
O00750-193-	SLVEQL...	193		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...SLISWD	60	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000409554
...YLYIFD	131	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000401795
...LTFTCN	395	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000356152
...SHGTL	1634	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)