O00754: Lysosomal alpha-mannosidase

General Information

Protein names	- Lysosomal alpha-mannosidase - Laman - 3.2.1.24 - Lysosomal acid alpha-mannosidase - Mannosidase alpha class 2B member 1 - Mannosidase alpha-B - Lysosomal alpha-mannosidase A peptide - Lysosomal alpha-mannosidase B peptide - Lysosomal alpha-mannosidase C peptide - Lysosomal alpha-mannosidase D peptide - Lysosomal alpha-mannosidase E peptide
Gene names	MAN2B1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O00754

9 N-termini

5 C-termini

0 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MGAYARASGV CARGCLDSAG PWTMSRALRP PLPPLCFFLL LLAAAGARAG GYETCPTVQP
        70         80         90        100        110        120
NMLNVHLLPH THDDVGWLKT VDQYFYGIKN DIQHAGVQYI LDSVISALLA DPTRRFIYVE
       130        140        150        160        170        180
IAFFSRWWHQ QTNATQEVVR DLVRQGRLEF ANGGWVMNDE AATHYGAIVD QMTLGLRFLE
       190        200        210        220        230        240
DTFGNDGRPR VAWHIDPFGH SREQASLFAQ MGFDGFFFGR LDYQDKWVRM QKLEMEQVWR
       250        260        270        280        290        300
ASTSLKPPTA DLFTGVLPNG YNPPRNLCWD VLCVDQPLVE DPRSPEYNAK ELVDYFLNVA
       310        320        330        340        350        360
TAQGRYYRTN HTVMTMGSDF QYENANMWFK NLDKLIRLVN AQQAKGSSVH VLYSTPACYL
       370        380        390        400        410        420
WELNKANLTW SVKHDDFFPY ADGPHQFWTG YFSSRPALKR YERLSYNFLQ VCNQLEALVG
       430        440        450        460        470        480
LAANVGPYGS GDSAPLNEAM AVLQHHDAVS GTSRQHVAND YARQLAAGWG PCEVLLSNAL
       490        500        510        520        530        540
ARLRGFKDHF TFCQQLNISI CPLSQTAARF QVIVYNPLGR KVNWMVRLPV SEGVFVVKDP
       550        560        570        580        590        600
NGRTVPSDVV IFPSSDSQAH PPELLFSASL PALGFSTYSV AQVPRWKPQA RAPQPIPRRS
       610        620        630        640        650        660
WSPALTIENE HIRATFDPDT GLLMEIMNMN QQLLLPVRQT FFWYNASIGD NESDQASGAY
       670        680        690        700        710        720
IFRPNQQKPL PVSRWAQIHL VKTPLVQEVH QNFSAWCSQV VRLYPGQRHL ELEWSVGPIP
       730        740        750        760        770        780
VGDTWGKEVI SRFDTPLETK GRFYTDSNGR EILERRRDYR PTWKLNQTEP VAGNYYPVNT
       790        800        810        820        830        840
RIYITDGNMQ LTVLTDRSQG GSSLRDGSLE LMVHRRLLKD DGRGVSEPLM ENGSGAWVRG
       850        860        870        880        890        900
RHLVLLDTAQ AAAAGHRLLA EQEVLAPQVV LAPGGGAAYN LGAPPRTQFS GLRRDLPPSV
       910        920        930        940        950        960
HLLTLASWGP EMVLLRLEHQ FAVGEDSGRN LSAPVTLNLR DLFSTFTITR LQETTLVANQ
       970        980        990       1000       1010
LREAASRLKW TTNTGPTPHQ TPYQLDPANI TLEPMEIRTF LASVQWKEVD G

Isoforms

- Isoform 2 of Lysosomal alpha-mannosidase

Sequence View

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

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Biological System:

Protease Assignment Confidence:

Evidence Names:

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Protein Neighborhood

Domains & Features

9 N-termini - 5 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
O00754-1-unknown	MGAYAR...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt80213
O00754-50-unknown	GGYETC...	50	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O00754-50-unknown	GGYETC...	50	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt115622
O00754-50-	GGYETC...	50		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
O00754-346-unknown	GSSVHV...	346	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O00754-346-unknown	GSSVHV...	346	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt116166
O00754-429-unknown	GSGDSA...	429	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt175851
O00754-429-	GSGDSA...	429		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
O00754-430-unknown	SGDSAP...	430	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O00754-430-unknown	SGDSAP...	430	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt116210
O00754-602-unknown	SPALTI...	602	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O00754-602-unknown	SPALTI...	602	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt116242
O00754-883-unknown	APPRTQ...	883	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O00754-883-unknown	APPRTQ...	883	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt116390

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...AQQAKG	345	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...VGPYGS	429	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...VGPYGS	429	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt92741
...PRRSWS	601	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...PRRSWS	601	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt93125
...AYNLGA	882	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...AYNLGA	882	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt93478
...KEVDG	1011	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...KEVDG	1011	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt75831

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)