O08528: Hexokinase-2

General Information

Protein names	- Hexokinase-2 - 2.7.1.1 - Hexokinase type II - HK II
Gene names	Hk2
Organism	Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID	O08528

5 N-termini

5 C-termini

3 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MIASHMIACL FTELNQNQVQ KVDQYLYHMR LSDETLLEIS RRFRKEMEKG LGATTHPTAA
        70         80         90        100        110        120
VKMLPTFVRS TPDGTEHGEF LALDLGGTNF RVLRVRVTDN GLQRVEMENQ IYAIPEDIMR
       130        140        150        160        170        180
GSGTQLFDHI AECLANFMDK LQIKEKKLPL GFTFSFPCHQ TKLDESFLVS WTKGFKSSGV
       190        200        210        220        230        240
EGRDVVDLIR KAIQRRGDFD IDIVAVVNDT VGTMMTCGYD DQNCEIGLIV GTGSNACYME
       250        260        270        280        290        300
EMRHIDMVEG DEGRMCINME WGAFGDDGTL NDIRTEFDRE IDMGSLNPGK QLFEKMISGM
       310        320        330        340        350        360
YMGELVRLIL VKMAKAELLF QGKLSPELLT TGSFETKDVS DIEDDKDGIQ KAYQILVRLG
       370        380        390        400        410        420
LSPLQEDCVA THRICQIVST RSASLCAATL AAVLWRIKEN KGEERLRSTI GVDGSVYKKH
       430        440        450        460        470        480
PHFAKRLHKA VRRLVPDCDV RFLRSEDGSG KGAAMVTAVA YRLADQHRAR QKTLESLKLS
       490        500        510        520        530        540
HEQLLEVKRR MKVEMEQGLS KETHEAAPVK MLPTYVCATP DGTEKGDFLA LDLGGTNFRV
       550        560        570        580        590        600
LLVRVRNGKR RGVEMHNKIY SIPQEVMHGT GEELFDHIVQ CIADFLEYMG MKGVSLPLGF
       610        620        630        640        650        660
TFSFPCQQNS LDQSILLKWT KGFKASGCEG EDVVTLLKEA IRRREEFDLD VVAVVNDTVG
       670        680        690        700        710        720
TMMTCGYEDP HCEVGLIVGT GSNACYMEEM RNVELVDGEE GRMCVNMEWG AFGDNGCLDD
       730        740        750        760        770        780
LRTVFDVAVD ELSLNPGKQR FEKMISGMYL GEIVRNILID FTKRGLLFRG RISERLKTRG
       790        800        810        820        830        840
IFETKFLSQI ESDCLALLQV RAILRHLGLE STCDDSIIVK EVCTVVARRA AQLCGAGMAA
       850        860        870        880        890        900
VVDKIRENRG LDNLKVTVGV DGTLYKLHPH FAKVMHETVR DLAPKCDVSF LESEDGSGKG
       910
AALITAVACR IREAGQR

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

5 N-termini - 5 C-termini - 3 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
O08528-1-unknown	MIASHM...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
O08528-29-unknown	MRLSDE...	29	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSMUSP00000125986
O08528-29-unknown	MRLSDE...	29	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSMUSP00000128572
O08528-81-unknown	LALDLG...	81	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29471
O08528-529-unknown	LALDLG...	529	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29472
O08528-891-unknown	LESEDG...	891	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29473

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...FVRSTP	71	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSMUSP00000128572
...EHGEFL	80	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29471
...EKGDFL	528	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29472
...CDVSFL	890	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29473
...EAGQR	917	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Evidence name
CATE_MOUSE	80	GEFL.\|.LALD	inferred from experiment	unknown	MEROPS	Merops CATE_MOUSE -> HXK2_MOUSE @80
CATE_MOUSE	528	GDFL.\|.LALD	inferred from experiment	unknown	MEROPS	Merops CATE_MOUSE -> HXK2_MOUSE @528
CATE_MOUSE	890	VSFL.\|.LESE	inferred from experiment	unknown	MEROPS	Merops CATE_MOUSE -> HXK2_MOUSE @890

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)