O08689: Growth/differentiation factor 8

General Information

Protein names	- Growth/differentiation factor 8 - GDF-8 - Myostatin
Gene names	Mstn
Organism	Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID	O08689

3 N-termini

2 C-termini

3 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MMQKLQMYVY IYLFMLIAAG PVDLNEGSER EENVEKEGLC NACAWRQNTR YSRIEAIKIQ
        70         80         90        100        110        120
ILSKLRLETA PNISKDAIRQ LLPRAPPLRE LIDQYDVQRD DSSDGSLEDD DYHATTETII
       130        140        150        160        170        180
TMPTESDFLM QADGKPKCCF FKFSSKIQYN KVVKAQLWIY LRPVKTPTTV FVQILRLIKP
       190        200        210        220        230        240
MKDGTRYTGI RSLKLDMSPG TGIWQSIDVK TVLQNWLKQP ESNLGIEIKA LDENGHDLAV
       250        260        270        280        290        300
TFPGPGEDGL NPFLEVKVTD TPKRSRRDFG LDCDEHSTES RCCRYPLTVD FEAFGWDWII
       310        320        330        340        350        360
APKRYKANYC SGECEFVFLQ KYPHTHLVHQ ANPRGSAGPC CTPTKMSPIN MLYFNGKEQI
       370
IYGKIPAMVV DRCGCS

Isoforms

Sequence View

Protein Neighborhood

Domains & Features

3 N-termini - 2 C-termini - 3 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
O08689-25-unknown	NEGSER...	25	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
O08689-100-unknown	DDSSDG...	100	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28308
O08689-100-unknown	DDSSDG...	100	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34812
O08689-100-unknown	DDSSDG...	100	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34815
O08689-268-unknown	DFGLDC...	268	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...YDVQRD	99	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28308
...YDVQRD	99	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34812
...YDVQRD	99	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34815
...RCGCS	376	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
BMP1_MOUSE	99	VQRD.\|.DDSS	inferred from experiment	unknown	MEROPS	Lee SJ	Wolfman NM et al.:Activation of latent myostatin ... (M12.005)	14671324,
TLL1_MOUSE	99	VQRD.\|.DDSS	inferred from experiment	unknown	MEROPS	Lee SJ	Wolfman NM et al.:Activation of latent myostatin ... (M12.005)	14671324,
TLL2_MOUSE	99	VQRD.\|.DDSS	inferred from experiment	unknown	MEROPS	Lee SJ	Wolfman NM et al.:Activation of latent myostatin ... (M12.005)	14671324,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

TopFIND

O08689: Growth/differentiation factor 8

General Information

3

N-termini

2

C-termini

3

Cleavages

0

Substrates

Sequence

Isoforms

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Protein Neighborhood

Domains & Features

3 N-termini - 2 C-termini - 3 Cleavages - 0 Substrates

N-termini

C-termini

Cleavages

Substrates