TopFIND 4.0

O14492: SH2B adapter protein 2

General Information

Protein names
- SH2B adapter protein 2
- Adapter protein with pleckstrin homology and Src homology 2 domains
- SH2 and PH domain-containing adapter protein APS
Gene names SH2B2
Organism Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID O14492

2

N-termini

3

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MNGAGPGPAA AAPVPVPVPV PDWRQFCELH AQAAAVDFAH KFCRFLRDNP AYDTPDAGAS 
        70         80         90        100        110        120 
FSRHFAANFL DVFGEEVRRV LVAGPTTRGA AVSAEAMEPE LADTSALKAA PYGHSRSSED 
       130        140        150        160        170        180 
VSTHAATKAR VRKGFSLRNM SLCVVDGVRD MWHRRASPEP DAAAAPRTAE PRDKWTRRLR 
       190        200        210        220        230        240 
LSRTLAAKVE LVDIQREGAL RFMVADDAAA GSGGSAQWQK CRLLLRRAVA EERFRLEFFV 
       250        260        270        280        290        300 
PPKASRPKVS IPLSAIIEVR TTMPLEMPEK DNTFVLKVEN GAEYILETID SLQKHSWVAD 
       310        320        330        340        350        360 
IQGCVDPGDS EEDTELSCTR GGCLASRVAS CSCELLTDAV DLPRPPETTA VGAVVTAPHS 
       370        380        390        400        410        420 
RGRDAVRESL IHVPLETFLQ TLESPGGSGS DSNNTGEQGA ETDPEAEPEL ELSDYPWFHG 
       430        440        450        460        470        480 
TLSRVKAAQL VLAGGPRNHG LFVIRQSETR PGEYVLTFNF QGKAKHLRLS LNGHGQCHVQ 
       490        500        510        520        530        540 
HLWFQSVLDM LRHFHTHPIP LESGGSADIT LRSYVRAQDP PPEPGPTPPA APASPACWSD 
       550        560        570        580        590        600 
SPGQHYFSSL AAAACPPASP SDAAGASSSS ASSSSAASGP APPRPVEGQL SARSRSNSAE 
       610        620        630    
RLLEAVAATA AEEPPEAAPG RARAVENQYS FY

Isoforms

- Isoform 2 of SH2B adapter protein 2

Sequence View

        10         20         30         40         50         60 
MNGAGPGPAA AAPVPVPVPV PDWRQFCELH AQAAAVDFAH KFCRFLRDNP AYDTPDAGAS 
        70         80         90        100        110        120 
FSRHFAANFL DVFGEEVRRV LVAGPTTRGA AVSAEAMEPE LADTSALKAA PYGHSRSSED 
       130        140        150        160        170        180 
VSTHAATKAR VRKGFSLRNM SLCVVDGVRD MWHRRASPEP DAAAAPRTAE PRDKWTRRLR 
       190        200        210        220        230        240 
LSRTLAAKVE LVDIQREGAL RFMVADDAAA GSGGSAQWQK CRLLLRRAVA EERFRLEFFV 
       250        260        270        280        290        300 
PPKASRPKVS IPLSAIIEVR TTMPLEMPEK DNTFVLKVEN GAEYILETID SLQKHSWVAD 
       310        320        330        340        350        360 
IQGCVDPGDS EEDTELSCTR GGCLASRVAS CSCELLTDAV DLPRPPETTA VGAVVTAPHS 
       370        380        390        400        410        420 
RGRDAVRESL IHVPLETFLQ TLESPGGSGS DSNNTGEQGA ETDPEAEPEL ELSDYPWFHG 
       430        440        450        460        470        480 
TLSRVKAAQL VLAGGPRNHG LFVIRQSETR PGEYVLTFNF QGKAKHLRLS LNGHGQCHVQ 
       490        500        510        520        530        540 
HLWFQSVLDM LRHFHTHPIP LESGGSADIT LRSYVRAQDP PPEPGPTPPA APASPACWSD 
       550        560        570        580        590        600 
SPGQHYFSSL AAAACPPASP SDAAGASSSS ASSSSAASGP APPRPVEGQL SARSRSNSAE 
       610        620        630    
RLLEAVAATA AEEPPEAAPG RARAVENQYS FY



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Physiological Relevance:


Evidence Codes:


Methodology:


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Protease Assignment Confidence:


Evidence Names:


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Protein Neighborhood

Domains & Features

2 N-termini - 3 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    O14492-1-unknown MNGAGP... 1 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    O14492-3- GAGPGP... 3 Subtiligase Based Positive Selection Wells apoptotic_MM1s_bort 23264352

C-termini

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)