TopFIND 4.0

O14512: Suppressor of cytokine signaling 7

General Information

Protein names
- Suppressor of cytokine signaling 7
- SOCS-7
- Nck, Ash and phospholipase C gamma-binding protein
- Nck-associated protein 4
- NAP-4
Gene names SOCS7
Organism Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID O14512

2

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MVFRNVGRPP EEEDVEAAPE PGPSELLCPR HRCALDPKAL PPGLALERTW GPAAGLEAQL 
        70         80         90        100        110        120 
AALGLGQPAG PGVKTVGGGC CPCPCPPQPP PPQPQPPAAA PQAGEDPTET SDALLVLEGL 
       130        140        150        160        170        180 
ESEAESLETN SCSEEELSSP GRGGGGGGRL LLQPPGPELP PVPFPLQDLV PLGRLSRGEQ 
       190        200        210        220        230        240 
QQQQQQQPPP PPPPPGPLRP LAGPSRKGSF KIRLSRLFRT KSCNGGSGGG DGTGKRPSGE 
       250        260        270        280        290        300 
LAASAASLTD MGGSAGRELD AGRKPKLTRT QSAFSPVSFS PLFTGETVSL VDVDISQRGL 
       310        320        330        340        350        360 
TSPHPPTPPP PPRRSLSLLD DISGTLPTSV LVAPMGSSLQ SFPLPPPPPP HAPDAFPRIA 
       370        380        390        400        410        420 
PIRAAESLHS QPPQHLQCPL YRPDSSSFAA SLRELEKCGW YWGPMNWEDA EMKLKGKPDG 
       430        440        450        460        470        480 
SFLVRDSSDP RYILSLSFRS QGITHHTRME HYRGTFSLWC HPKFEDRCQS VVEFIKRAIM 
       490        500        510        520        530        540 
HSKNGKFLYF LRSRVPGLPP TPVQLLYPVS RFSNVKSLQH LCRFRIRQLV RIDHIPDLPL 
       550        560        570        580    
PKPLISYIRK FYYYDPQEEV YLSLKEAQLI SKQKQEVEPS T

Isoforms

- Isoform 2 of Suppressor of cytokine signaling 7

Sequence View

        10         20         30         40         50         60 
MVFRNVGRPP EEEDVEAAPE PGPSELLCPR HRCALDPKAL PPGLALERTW GPAAGLEAQL 
        70         80         90        100        110        120 
AALGLGQPAG PGVKTVGGGC CPCPCPPQPP PPQPQPPAAA PQAGEDPTET SDALLVLEGL 
       130        140        150        160        170        180 
ESEAESLETN SCSEEELSSP GRGGGGGGRL LLQPPGPELP PVPFPLQDLV PLGRLSRGEQ 
       190        200        210        220        230        240 
QQQQQQQPPP PPPPPGPLRP LAGPSRKGSF KIRLSRLFRT KSCNGGSGGG DGTGKRPSGE 
       250        260        270        280        290        300 
LAASAASLTD MGGSAGRELD AGRKPKLTRT QSAFSPVSFS PLFTGETVSL VDVDISQRGL 
       310        320        330        340        350        360 
TSPHPPTPPP PPRRSLSLLD DISGTLPTSV LVAPMGSSLQ SFPLPPPPPP HAPDAFPRIA 
       370        380        390        400        410        420 
PIRAAESLHS QPPQHLQCPL YRPDSSSFAA SLRELEKCGW YWGPMNWEDA EMKLKGKPDG 
       430        440        450        460        470        480 
SFLVRDSSDP RYILSLSFRS QGITHHTRME HYRGTFSLWC HPKFEDRCQS VVEFIKRAIM 
       490        500        510        520        530        540 
HSKNGKFLYF LRSRVPGLPP TPVQLLYPVS RFSNVKSLQH LCRFRIRQLV RIDHIPDLPL 
       550        560        570        580    
PKPLISYIRK FYYYDPQEEV YLSLKEAQLI SKQKQEVEPS T



Filter Information:


(REFRESH)

Directness:


Physiological Relevance:


Evidence Codes:


Methodology:


Perturbation of System:


Biological System:


Protease Assignment Confidence:


Evidence Names:


Database:


Lab:



Protein Neighborhood

Domains & Features

2 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    O14512-1-unknown MVFRNV... 1 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    O14512-251-unknown MGGSAG... 251 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt90227

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...VEPST 581 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    ...VEPST 581 inferred from isoform by sequence similarity unknown TopFIND inferred from TCt85845

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)