O14733: Dual specificity mitogen-activated protein kinase kinase 7

General Information

Protein names	- Dual specificity mitogen-activated protein kinase kinase 7 - MAP kinase kinase 7 - MAPKK 7 - 2.7.12.2 - JNK-activating kinase 2 - MAPK/ERK kinase 7 - MEK 7 - Stress-activated protein kinase kinase 4 - SAPK kinase 4 - SAPKK-4 - SAPKK4 - c-Jun N-terminal kinase kinase 2 - JNK kinase 2 - JNKK 2
Gene names	MAP2K7
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O14733

3 N-termini

1 C-termini

0 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Dual specificity mitogen-activated protein kinase kinase 7 - Isoform 3 of Dual specificity mitogen-activated protein kinase kinase 7 - Isoform 4 of Dual specificity mitogen-activated protein kinase kinase 7

Sequence View

        10         20         30         40         50         60
MAASSLEQKL SRLEAKLKQE NREARRRIDL NLDISPQRPR PTLQLPLAND GGSRSPSSES
        70         80         90        100        110        120
SPQHPTPPAR PRHMLGLPST LFTPRSMESI EIDQKLQEIM KQTGYLTIGG QRYQAEINDL
       130        140        150        160        170        180
ENLGEMGSGT CGQVWKMRFR KTGHVIAVKQ MRRSGNKEEN KRILMDLDVV LKSHDCPYIV
       190        200        210        220        230        240
QCFGTFITNT DVFIAMELMG TCAEKLKKRM QGPIPERILG KMTVAIVKAL YYLKEKHGVI
       250        260        270        280        290        300
HRDVKPSNIL LDERGQIKLC DFGISGRLVD SKAKTRSAGC AAYMAPERID PPDPTKPDYD
       310        320        330        340        350        360
IRADVWSLGI SLVELATGQF PYKNCKTDFE VLTKVLQEEP PLLPGHMGFS GDFQSFVKDC
       370        380        390        400        410
LTKDHRKRPK YNKLLEHSFI KRYETLEVDV ASWFKDVMAK TESPRTSGVL SQPHLPFFR         10         20         30         40         50         60
MAASSLEQKL SRLEAKLKQE NREARRRIDL NLDISPQRPR PTLQLPLAND GGSRSPSSES
        70         80         90        100        110        120
SPQHPTPPAR PRHMLGLPST LFTPRSMESI EIDQKLQEIM KQTGYLTIGG QRYQAEINDL
       130        140        150        160        170        180
ENLGEMGSGT CGQVWKMRFR KTGHVIAVKQ MRRSGNKEEN KRILMDLDVV LKSHDCPYIV
       190        200        210        220        230        240
QCFGTFITNT DVFIAMELMG TCAEKLKKRM QGPIPERILG KMTVAIVKAL YYLKEKHGVI
       250        260        270        280        290        300
HRDVKPSNIL LDERGQIKLC DFGISGRLVD SKAKTRSAGC AAYMAPERID PPDPTKPDYD
       310        320        330        340        350        360
IRADVWSLGI SLVELATGQF PYKNCKTDFE VLTKVLQEEP PLLPGHMGFS GDFQSFVKDC
       370        380        390        400        410
LTKDHRKRPK YNKLLEHSFI KRYETLEVDV ASWFKDVMAK TESPRTSGVL SQPHLPFFR         10         20         30         40         50         60
MAASSLEQKL SRLEAKLKQE NREARRRIDL NLDISPQRPR PTLQLPLAND GGSRSPSSES
        70         80         90        100        110        120
SPQHPTPPAR PRHMLGLPST LFTPRSMESI EIDQKLQEIM KQTGYLTIGG QRYQAEINDL
       130        140        150        160        170        180
ENLGEMGSGT CGQVWKMRFR KTGHVIAVKQ MRRSGNKEEN KRILMDLDVV LKSHDCPYIV
       190        200        210        220        230        240
QCFGTFITNT DVFIAMELMG TCAEKLKKRM QGPIPERILG KMTVAIVKAL YYLKEKHGVI
       250        260        270        280        290        300
HRDVKPSNIL LDERGQIKLC DFGISGRLVD SKAKTRSAGC AAYMAPERID PPDPTKPDYD
       310        320        330        340        350        360
IRADVWSLGI SLVELATGQF PYKNCKTDFE VLTKVLQEEP PLLPGHMGFS GDFQSFVKDC
       370        380        390        400        410
LTKDHRKRPK YNKLLEHSFI KRYETLEVDV ASWFKDVMAK TESPRTSGVL SQPHLPFFR

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

3 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
O14733-2-unknown	MAASSL...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O14733-1-unknown	MAASSL...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt81436
O14733-1-unknown	MAASSL...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt81437
O14733-1-unknown	MAASSL...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt81438
O14733-2-Acetylation	AASSLE...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O14733-2-Acetylation	AASSLE...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
O14733-2-Acetylation	AASSLE...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
O14733-2-Acetylation	AASSLE...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt111573
O14733-2-Acetylation	AASSLE...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt111574
O14733-2-Acetylation	AASSLE...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt111575

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...LPFFR	419	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...LPFFR	419	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt77056
...LPFFR	419	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt77055
...LPFFR	419	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt77054

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)