O14757: Serine/threonine-protein kinase Chk1

General Information

Protein names	- Serine/threonine-protein kinase Chk1 - 2.7.11.1 - CHK1 checkpoint homolog - Cell cycle checkpoint kinase - Checkpoint kinase-1
Gene names	CHEK1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O14757

5 N-termini

1 C-termini

0 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Serine/threonine-protein kinase Chk1 - Isoform 3 of Serine/threonine-protein kinase Chk1

Sequence View

        10         20         30         40         50         60
MAVPFVEDWD LVQTLGEGAY GEVQLAVNRV TEEAVAVKIV DMKRAVDCPE NIKKEICINK
        70         80         90        100        110        120
MLNHENVVKF YGHRREGNIQ YLFLEYCSGG ELFDRIEPDI GMPEPDAQRF FHQLMAGVVY
       130        140        150        160        170        180
LHGIGITHRD IKPENLLLDE RDNLKISDFG LATVFRYNNR ERLLNKMCGT LPYVAPELLK
       190        200        210        220        230        240
RREFHAEPVD VWSCGIVLTA MLAGELPWDQ PSDSCQEYSD WKEKKTYLNP WKKIDSAPLA
       250        260        270        280        290        300
LLHKILVENP SARITIPDIK KDRWYNKPLK KGAKRPRVTS GGVSESPSGF SKHIQSNLDF
       310        320        330        340        350        360
SPVNSASSEE NVKYSSSQPE PRTGLSLWDT SPSYIDKLVQ GISFSQPTCP DHMLLNSQLL
       370        380        390        400        410        420
GTPGSSQNPW QRLVKRMTRF FTKLDADKSY QCLKETCEKL GYQWKKSCMN QVTISTTDRR
       430        440        450        460        470
NNKLIFKVNL LEMDDKILVD FRLSKGDGLE FKRHFLKIKG KLIDIVSSQK IWLPAT         10         20         30         40         50         60
MAVPFVEDWD LVQTLGEGAY GEVQLAVNRV TEEAVAVKIV DMKRAVDCPE NIKKEICINK
        70         80         90        100        110        120
MLNHENVVKF YGHRREGNIQ YLFLEYCSGG ELFDRIEPDI GMPEPDAQRF FHQLMAGVVY
       130        140        150        160        170        180
LHGIGITHRD IKPENLLLDE RDNLKISDFG LATVFRYNNR ERLLNKMCGT LPYVAPELLK
       190        200        210        220        230        240
RREFHAEPVD VWSCGIVLTA MLAGELPWDQ PSDSCQEYSD WKEKKTYLNP WKKIDSAPLA
       250        260        270        280        290        300
LLHKILVENP SARITIPDIK KDRWYNKPLK KGAKRPRVTS GGVSESPSGF SKHIQSNLDF
       310        320        330        340        350        360
SPVNSASSEE NVKYSSSQPE PRTGLSLWDT SPSYIDKLVQ GISFSQPTCP DHMLLNSQLL
       370        380        390        400        410        420
GTPGSSQNPW QRLVKRMTRF FTKLDADKSY QCLKETCEKL GYQWKKSCMN QVTISTTDRR
       430        440        450        460        470
NNKLIFKVNL LEMDDKILVD FRLSKGDGLE FKRHFLKIKG KLIDIVSSQK IWLPAT

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

5 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
O14757-1-unknown	MAVPFV...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O14757-1-unknown	MAVPFV...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt70559
O14757-300-	FSPVNS...	300		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
O14757-300-unknown	FSPVNS...	300	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt177873
O14757-300-unknown	FSPVNS...	300	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt177872
O14757-305-unknown	SASSEE...	305	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt177870
O14757-305-unknown	SASSEE...	305	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt177869
O14757-305-	SASSEE...	305		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...WLPAT	476	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...WLPAT	476	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt66176
...WLPAT	476	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt66177

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)