O14777: Kinetochore protein NDC80 homolog

General Information

Protein names	- Kinetochore protein NDC80 homolog - Highly expressed in cancer protein - Kinetochore protein Hec1 - HsHec1 - Kinetochore-associated protein 2 - Retinoblastoma-associated protein HEC
Gene names	NDC80
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O14777

3 N-termini

2 C-termini

0 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MKRSSVSSGG AGRLSMQELR SQDVNKQGLY TPQTKEKPTF GKLSINKPTS ERKVSLFGKR
        70         80         90        100        110        120
TSGHGSRNSQ LGIFSSSEKI KDPRPLNDKA FIQQCIRQLC EFLTENGYAH NVSMKSLQAP
       130        140        150        160        170        180
SVKDFLKIFT FLYGFLCPSY ELPDTKFEEE VPRIFKDLGY PFALSKSSMY TVGAPHTWPH
       190        200        210        220        230        240
IVAALVWLID CIKIHTAMKE SSPLFDDGQP WGEETEDGIM HNKLFLDYTI KCYESFMSGA
       250        260        270        280        290        300
DSFDEMNAEL QSKLKDLFNV DAFKLESLEA KNRALNEQIA RLEQEREKEP NRLESLRKLK
       310        320        330        340        350        360
ASLQGDVQKY QAYMSNLESH SAILDQKLNG LNEEIARVEL ECETIKQENT RLQNIIDNQK
       370        380        390        400        410        420
YSVADIERIN HERNELQQTI NKLTKDLEAE QQKLWNEELK YARGKEAIET QLAEYHKLAR
       430        440        450        460        470        480
KLKLIPKGAE NSKGYDFEIK FNPEAGANCL VKYRAQVYVP LKELLNETEE EINKALNKKM
       490        500        510        520        530        540
GLEDTLEQLN AMITESKRSV RTLKEEVQKL DDLYQQKIKE AEEEDEKCAS ELESLEKHKH
       550        560        570        580        590        600
LLESTVNQGL SEAMNELDAV QREYQLVVQT TTEERRKVGN NLQRLLEMVA THVGSVEKHL
       610        620        630        640
EEQIAKVDRE YEECMSEDLS ENIKEIRDKY EKKATLIKSS EE

Isoforms

Sequence View

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

3 N-termini - 2 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
O14777-1-unknown	MKRSSV...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
O14777-95-unknown	CIRQLC...	95	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000476919
O14777-571-unknown	TTEERR...	571	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000458236

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...KSSEE	642	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...KSSEE	642		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...KSSEE	642		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,
...KSSEE	642		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...KSSEE	642		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)