O14788: Tumor necrosis factor ligand superfamily member 11

General Information

Protein names	- Tumor necrosis factor ligand superfamily member 11 - Osteoclast differentiation factor - ODF - Osteoprotegerin ligand - OPGL - Receptor activator of nuclear factor kappa-B ligand - RANKL - TNF-related activation-induced cytokine - TRANCE - CD254 - Tumor necrosis factor ligand superfamily member 11, membrane form - Tumor necrosis factor ligand superfamily member 11, soluble form
Gene names	TNFSF11
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O14788

4 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Tumor necrosis factor ligand superfamily member 11 - Isoform 3 of Tumor necrosis factor ligand superfamily member 11

Sequence View

        10         20         30         40         50         60
MRRASRDYTK YLRGSEEMGG GPGAPHEGPL HAPPPPAPHQ PPAASRSMFV ALLGLGLGQV
        70         80         90        100        110        120
VCSVALFFYF RAQMDPNRIS EDGTHCIYRI LRLHENADFQ DTTLESQDTK LIPDSCRRIK
       130        140        150        160        170        180
QAFQGAVQKE LQHIVGSQHI RAEKAMVDGS WLDLAKRSKL EAQPFAHLTI NATDIPSGSH
       190        200        210        220        230        240
KVSLSSWYHD RGWAKISNMT FSNGKLIVNQ DGFYYLYANI CFRHHETSGD LATEYLQLMV
       250        260        270        280        290        300
YVTKTSIKIP SSHTLMKGGS TKYWSGNSEF HFYSINVGGF FKLRSGEEIS IEVSNPSLLD
       310
PDQDATYFGA FKVRDID         10         20         30         40         50         60
MRRASRDYTK YLRGSEEMGG GPGAPHEGPL HAPPPPAPHQ PPAASRSMFV ALLGLGLGQV
        70         80         90        100        110        120
VCSVALFFYF RAQMDPNRIS EDGTHCIYRI LRLHENADFQ DTTLESQDTK LIPDSCRRIK
       130        140        150        160        170        180
QAFQGAVQKE LQHIVGSQHI RAEKAMVDGS WLDLAKRSKL EAQPFAHLTI NATDIPSGSH
       190        200        210        220        230        240
KVSLSSWYHD RGWAKISNMT FSNGKLIVNQ DGFYYLYANI CFRHHETSGD LATEYLQLMV
       250        260        270        280        290        300
YVTKTSIKIP SSHTLMKGGS TKYWSGNSEF HFYSINVGGF FKLRSGEEIS IEVSNPSLLD
       310
PDQDATYFGA FKVRDID

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

4 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
O14788-1-unknown	MRRASR...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
O14788-48-unknown	MFVALL...	48	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt92590
O14788-48-unknown	MFVALL...	48	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
O14788-74-unknown	MDPNRI...	74	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt92589
O14788-74-unknown	MDPNRI...	74	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt105565
O14788-140-unknown	IRAEKA...	140	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
O14788-140-unknown	IRAEKA...	140	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC166
O14788-140-unknown	IRAEKA...	140	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt115945
O14788-140-unknown	IRAEKA...	140	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt115944

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...VGSQHI	139	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC166
...VGSQHI	139	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt123576
...VGSQHI	139	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt125213
...VRDID	317	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...VRDID	317	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt88207
...VRDID	317	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt88208

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
ADA33_HUMAN	139	SQHI.\|.IRAE	inferred from experiment	unknown	MEROPS	Umland SP	Zou J et al.:Catalytic activity of human ADA... (M12.244)	14676211,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)